IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2008 181: 4431-4432. [Full Text] [PDF] ImmunoCast  

LETTERS TO THE EDITOR:

Comment on "Local Accumulation of FOXP3⁺ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata"

Mark R. Goldstein, Luca Mascitelli, and Francesca Pezzetta
J Immunol 2008 181: 4433. [Full Text] [PDF]  

Response to Comment on "Local Accumulation of FOXP3⁺ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata"

Yuchun Cao, Jie Zhao, and Bo Huang
J Immunol 2008 181: 4433-4434. [Full Text] [PDF]  

PILLARS OF IMMUNOLOGY:

Th1 Fate Determination in CD4⁺ T Cells: Notice Is Served of the Importance of IL-12!

William E. Paul
J Immunol 2008 181: 4435-4436. [Full Text] [PDF] [Original Pillars Article]  

Pillars Article: Development of T_H1 CD4⁺ T Cells Through IL-12 Produced by Listeria-Induced Macrophages. 1993. Science 260(5107): 547–549

Chyi-Song Hsieh, Steven E. Macatonia, Catherine S. Tripp, Stanley F. Wolf, Anne O'Garra, and Kenneth M. Murphy
J Immunol 2008 181: 4437-4439. [PDF]  

BRIEF REVIEWS:

Transcriptional Outcome of Wnt-Frizzled Signal Transduction in Inflammation: Evolving Concepts

Malini Sen and Gourisankar Ghosh
J Immunol 2008 181: 4441-4445. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: CD25⁺ Regulatory T Cells Prevent Expansion and Induce Apoptosis of B Cells Specific for Tissue Autoantigens

Isis Ludwig-Portugall, Emma E. Hamilton-Williams, Catherine Gottschalk, and Christian Kurts
J Immunol 2008 181: 4447-4451. [Abstract] [Full Text] [PDF] Data Supplement  

Cutting Edge: The Mechanism of Invariant NKT Cell Responses to Viral Danger Signals

Aaron J. Tyznik, Emmanuel Tupin, Niranjana A. Nagarajan, Min J. Her, Chris A. Benedict, and Mitchell Kronenberg
J Immunol 2008 181: 4452-4456. [Abstract] [Full Text] [PDF]  

Cutting Edge: IL-1 Controls the IL-23 Response Induced by Gliadin, the Etiologic Agent in Celiac Disease

Kristina M. Harris, Alessio Fasano, and Dean L. Mann
J Immunol 2008 181: 4457-4460. [Abstract] [Full Text] [PDF] Data Supplement  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

IFN--Induced TNF- Expression Is Regulated by Interferon Regulatory Factors 1 and 8 in Mouse Macrophages

Virginia Vila-del Sol, Carmen Punzón, and Manuel Fresno
J Immunol 2008 181: 4461-4470. [Abstract] [Full Text] [PDF]  

Only a Subset of Phosphoantigen-Responsive ₉₂ T Cells Mediate Protective Tuberculosis Immunity

Charles T. Spencer, Getahun Abate, Azra Blazevic, and Daniel F. Hoft
J Immunol 2008 181: 4471-4484. [Abstract] [Full Text] [PDF]  

Hepatitis C Virus-Specific Th17 Cells Are Suppressed by Virus-Induced TGF-β

Aileen G. Rowan, Jean M. Fletcher, Elizabeth J. Ryan, Barry Moran, John E. Hegarty, Cliona O'Farrelly, and Kingston H. G. Mills
J Immunol 2008 181: 4485-4494. [Abstract] [Full Text] [PDF]  

Lentiviral-Mediated Transcriptional Targeting of Dendritic Cells for Induction of T Cell Tolerance In Vivo

Christiane Dresch, Stephanie L. Edelmann, Peggy Marconi, and Thomas Brocker
J Immunol 2008 181: 4495-4506. [Abstract] [Full Text] [PDF]  

Umbilical Cord Blood T Cells Express Multiple Natural Cytotoxicity Receptors after IL-15 Stimulation, but Only NKp30 Is Functional

Qin Tang, Bartosz Grzywacz, Hongbo Wang, Nandini Kataria, Qing Cao, John E. Wagner, Bruce R. Blazar, Jeffrey S. Miller, and Michael R. Verneris
J Immunol 2008 181: 4507-4515. [Abstract] [Full Text] [PDF]  

Regulatory T Cells Prevent Transfer of Type 1 Diabetes in NOD Mice Only When Their Antigen Is Present In Vivo

Daniel R. Tonkin, Jing He, Gene Barbour, and Kathryn Haskins
J Immunol 2008 181: 4516-4522. [Abstract] [Full Text] [PDF]  

Promoter Analysis Reveals Critical Roles for SMAD-3 and ATF-2 in Expression of IL-23 p19 in Macrophages

Fahd Al-Salleeh and Thomas M. Petro
J Immunol 2008 181: 4523-4533. [Abstract] [Full Text] [PDF]  

Bone Marrow-Derived Dendritic Cells Generated in the Presence of Resolvin E1 Induce Apoptosis of Activated CD4⁺ T Cells

Evros K. Vassiliou, Olga M. Kesler, James H. Tadros, and Doina Ganea
J Immunol 2008 181: 4534-4544. [Abstract] [Full Text] [PDF]  

Disruption of the Transcription Factor Nrf2 Promotes Pro-Oxidative Dendritic Cells That Stimulate Th2-Like Immunoresponsiveness upon Activation by Ambient Particulate Matter

Marc A. Williams, Tirumalai Rangasamy, Stephen M. Bauer, Smruti Killedar, Matthew Karp, Thomas W. Kensler, Masayuki Yamamoto, Patrick Breysse, Shyam Biswal, and Steve N. Georas
J Immunol 2008 181: 4545-4559. [Abstract] [Full Text] [PDF]  

Activation of Nonclassical CD1d-Restricted NK T Cells Induces Airway Hyperreactivity in β₂-Microglobulin-Deficient Mice

Youngil I. Koh, Hye Young Kim, Everett H. Meyer, Muriel Pichavant, Omid Akbari, Takahiro Yasumi, Paul B. Savage, Rosemarie H. DeKruyff, and Dale T. Umetsu
J Immunol 2008 181: 4560-4569. [Abstract] [Full Text] [PDF]  

Galectin-1 Promotes Immunoglobulin Production during Plasma Cell Differentiation

Chih-Ming Tsai, Yi-Kai Chiu, Tsui-Ling Hsu, I-Ying Lin, Shie-Liang Hsieh, and Kuo-I Lin
J Immunol 2008 181: 4570-4579. [Abstract] [Full Text] [PDF]  

Donor Deficiency of Decay-Accelerating Factor Accelerates Murine T Cell-Mediated Cardiac Allograft Rejection

Vasile Pavlov, Hugo Raedler, Shuguang Yuan, Staci Leisman, Wing-hong Kwan, Peter N. Lalli, M. Edward Medof, and Peter S. Heeger
J Immunol 2008 181: 4580-4589. [Abstract] [Full Text] [PDF]  

Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response

Murali Gururajan, Alan Simmons, Trivikram Dasu, Brett T. Spear, Christopher Calulot, Darrell A. Robertson, David L. Wiest, John G. Monroe, and Subbarao Bondada
J Immunol 2008 181: 4590-4602. [Abstract] [Full Text] [PDF]  

Differential Susceptibility of Allogeneic Targets to Indirect CD4 Immunity Generates Split Tolerance

William F. N. Chan, Haide Razavy, and Colin C. Anderson
J Immunol 2008 181: 4603-4612. [Abstract] [Full Text] [PDF]  

T Cells from Leishmania major-Susceptible BALB/c Mice Have a Defect in Efficiently Up-Regulating CXCR3 upon Activation

Joseph Barbi, Frank Brombacher, and Abhay R. Satoskar
J Immunol 2008 181: 4613-4620. [Abstract] [Full Text] [PDF]  

Induction of a VLA-2 (CD49b)-Expressing Effector T Cell Population by a Cell-Based Neuroblastoma Vaccine Expressing CD137L

Xiaocai Yan, Bryon D. Johnson, and Rimas J. Orentas
J Immunol 2008 181: 4621-4631. [Abstract] [Full Text] [PDF]  

Monocyte Migration and LFA-1-Mediated Attachment to Brain Microvascular Endothelia Is Regulated by SDF-1 through Lyn Kinase

Mobeen Malik, Ying-Yu Chen, Martha F. Kienzle, Brian E. Tomkowicz, Ronald G. Collman, and Andrzej Ptasznik
J Immunol 2008 181: 4632-4637. [Abstract] [Full Text] [PDF]  

Intrinsic and Induced Regulation of the Age-Associated Onset of Spontaneous Experimental Autoimmune Encephalomyelitis

Hong Zhang, Joseph R. Podojil, Xunrong Luo, and Stephen D. Miller
J Immunol 2008 181: 4638-4647. [Abstract] [Full Text] [PDF]  

Swift Entry of Myelin-Specific T Lymphocytes into the Central Nervous System in Spontaneous Autoimmune Encephalomyelitis

Gláucia C. Furtado, Maria Cecilia G. Marcondes, Jo-Ann Latkowski, Julia Tsai, Allen Wensky, and Juan J. Lafaille
J Immunol 2008 181: 4648-4655. [Abstract] [Full Text] [PDF]  

Novel Role of IL-13 in Fibrosis Induced by Nonalcoholic Steatohepatitis and Its Amelioration by IL-13R-Directed Cytotoxin in a Rat Model

Takeshi Shimamura, Toshio Fujisawa, Syed R. Husain, Mitomu Kioi, Atsushi Nakajima, and Raj K. Puri
J Immunol 2008 181: 4656-4665. [Abstract] [Full Text] [PDF]  

Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells

Pratima Sinha, Chinonyerem Okoro, Dirk Foell, Hudson H. Freeze, Suzanne Ostrand-Rosenberg, and Geetha Srikrishna
J Immunol 2008 181: 4666-4675. [Abstract] [Full Text] [PDF]  

A Novel Role for CD4⁺ T Cells in the Control of Cachexia

Zhuangzhi Wang, Chunfang Zhao, Rosa Moya, and Joanna D. Davies
J Immunol 2008 181: 4676-4684. [Abstract] [Full Text] [PDF]  

Nicotinamide Phosphoribosyl Transferase/Pre-B Cell Colony-Enhancing Factor/Visfatin Is Required for Lymphocyte Development and Cellular Resistance to Genotoxic Stress

Anthony Rongvaux, Mara Galli, Sébastien Denanglaire, Frédéric Van Gool, Pierre L. Drèze, Claude Szpirer, Fabrice Bureau, Fabienne Andris, and Oberdan Leo
J Immunol 2008 181: 4685-4695. [Abstract] [Full Text] [PDF] Data Supplement  

Protein Kinase C- Is Required for Efficient Positive Selection

Sharon Celeste Morley, K. Scott Weber, Henry Kao, and Paul M. Allen
J Immunol 2008 181: 4696-4708. [Abstract] [Full Text] [PDF]  

Goblet Cell-Derived Resistin-Like Molecule β Augments CD4⁺ T Cell Production of IFN- and Infection-Induced Intestinal Inflammation

Meera G. Nair, Katherine J. Guild, Yurong Du, Colby Zaph, George D. Yancopoulos, David M. Valenzuela, Andrew Murphy, Sean Stevens, Margaret Karow, and David Artis
J Immunol 2008 181: 4709-4715. [Abstract] [Full Text] [PDF]  

Protein Kinase C Localizes to Secretory Lysosomes in CD8⁺ CTL and Directly Mediates TCR Signals Leading to Granule Exocytosis-Mediated Cytotoxicity

Jennifer S. Y. Ma, Tarik F. Haydar, and Sasa Radoja
J Immunol 2008 181: 4716-4722. [Abstract] [Full Text] [PDF] Data Supplement  

Arrestin 3 Mediates Endocytosis of CCR7 following Ligation of CCL19 but Not CCL21

Melissa A. Byers, Psachal A. Calloway, Laurie Shannon, Heather D. Cunningham, Sarah Smith, Fang Li, Brian C. Fassold, and Charlotte M. Vines
J Immunol 2008 181: 4723-4732. [Abstract] [Full Text] [PDF]  

Induction of IL-17⁺ T Cell Trafficking and Development by IFN-: Mechanism and Pathological Relevance in Psoriasis

Ilona Kryczek, Allen T. Bruce, Johann E. Gudjonsson, Andrew Johnston, Abhishek Aphale, Linhua Vatan, Wojciech Szeliga, Yin Wang, Yan Liu, Theodore H. Welling, James T. Elder, and Weiping Zou
J Immunol 2008 181: 4733-4741. [Abstract] [Full Text] [PDF]  

Inhibitory Immunoglobulin-Like Receptors LILRB and PIR-B Negatively Regulate Osteoclast Development

Yu Mori, Sukenao Tsuji, Masanori Inui, Yuzuru Sakamoto, Shota Endo, Yumi Ito, Shion Fujimura, Takako Koga, Akira Nakamura, Hiroshi Takayanagi, Eiji Itoi, and Toshiyuki Takai
J Immunol 2008 181: 4742-4751. [Abstract] [Full Text] [PDF]  

Transplantation Survival Is Maintained by Granzyme B⁺ Regulatory Cells and Adaptive Regulatory T Cells

David C. Gondek, Victor DeVries, Elizabeth C. Nowak, Li-Fan Lu, Kathryn A. Bennett, Zachary A. Scott, and Randolph J. Noelle
J Immunol 2008 181: 4752-4760. [Abstract] [Full Text] [PDF]  

Two Distinct T Cell Subsets, CD4⁺ and CD8⁺CD60⁺, and Their Cytokines Are Required for In Vitro Induction of Human Ragweed-Specific Memory IgE Responses

Tamar A. Smith-Norowitz, Jonathan Silverberg, Kevin B. Norowitz, Martin H. Bluth, Seto Chice, Rauno Joks, Maja Nowakowski, and Helen G. Durkin
J Immunol 2008 181: 4761-4769. [Abstract] [Full Text] [PDF]  

Impact of Mammalian Target of Rapamycin Inhibition on Lymphoid Homing and Tolerogenic Function of Nanoparticle-Labeled Dendritic Cells following Allogeneic Hematopoietic Cell Transplantation

Wilfried Reichardt, Christoph Dürr, Dominik von Elverfeldt, Eva Jüttner, Ulrike V. Gerlach, Mayumi Yamada, Benjie Smith, Robert S. Negrin, and Robert Zeiser
J Immunol 2008 181: 4770-4779. [Abstract] [Full Text] [PDF]  

IL-33 Induces Antigen-Specific IL-5⁺ T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4

Mariola Kurowska-Stolarska, Pete Kewin, Grace Murphy, Remo C. Russo, Bartosz Stolarski, Cristiana Couto Garcia, Mousa Komai-Koma, Nick Pitman, Yubin Li, Andrew N. J. McKenzie, Mauro M. Teixeira, Foo Y. Liew, and Damo Xu
J Immunol 2008 181: 4780-4790. [Abstract] [Full Text] [PDF]  

Activation of Invariant NKT Cells Ameliorates Experimental Ocular Autoimmunity by A Mechanism Involving Innate IFN- Production and Dampening of the Adaptive Th1 and Th17 Responses

Rafael S. Grajewski, Anna M. Hansen, Rajeev K. Agarwal, Mitchell Kronenberg, Stephane Sidobre, Shao Bo Su, Phyllis B. Silver, Moriya Tsuji, Richard W. Franck, Anne P. Lawton, Chi-Chao Chan, and Rachel R. Caspi
J Immunol 2008 181: 4791-4797. [Abstract] [Full Text] [PDF]  

Definition of APC Presentation of Phosphoantigen (E)-4-Hydroxy-3-methyl-but-2-enyl Pyrophosphate to V2V2 TCR

Huiyong Wei, Dan Huang, Xiaomin Lai, Meiling Chen, Weihua Zhong, Richard Wang, and Zheng W. Chen
J Immunol 2008 181: 4798-4806. [Abstract] [Full Text] [PDF]  

Vaccination-Induced Systemic Autoimmunity in Farmed Atlantic Salmon

Erling O. Koppang, Inge Bjerkås, Erlend Haugarvoll, Edward K. L. Chan, Nancy J. Szabo, Nobutaka Ono, Bunshiro Akikusa, Emilio Jirillo, Trygve T. Poppe, Harald Sveier, Brit Tørud, and Minoru Satoh
J Immunol 2008 181: 4807-4814. [Abstract] [Full Text] [PDF]  

Protein Kinase C Regulates Stability of the Peripheral Adhesion Ring Junction and Contributes to the Sensitivity of Target Cell Lysis by CTL

Allison M. Beal, Nadia Anikeeva, Rajat Varma, Thomas O. Cameron, Philip J. Norris, Michael L. Dustin, and Yuri Sykulev
J Immunol 2008 181: 4815-4824. [Abstract] [Full Text] [PDF] Data Supplement  

Bone Marrow Precursor Cells from Aged Mice Generate CD4 T Cells That Function Well in Primary and Memory Responses

Sheri M. Eaton, Alexander C. Maue, Susan L. Swain, and Laura Haynes
J Immunol 2008 181: 4825-4831. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

NFATc1 Regulates PD-1 Expression upon T Cell Activation

Kenneth J. Oestreich, Hyesuk Yoon, Rafi Ahmed, and Jeremy M. Boss
J Immunol 2008 181: 4832-4839. [Abstract] [Full Text] [PDF] Data Supplement  

Distinct Regulation of Integrin-Dependent T Cell Conjugate Formation and NF-B Activation by the Adapter Protein ADAP

Brandon J. Burbach, Rupa Srivastava, Ricardo B. Medeiros, William E. O'Gorman, Erik J. Peterson, and Yoji Shimizu
J Immunol 2008 181: 4840-4851. [Abstract] [Full Text] [PDF]  

T Cell-Dendritic Cell Immunological Synapses Contain TCR-dependent CD28-CD80 Clusters That Recruit Protein Kinase C

Su-Yi Tseng, Janelle C. Waite, Mengling Liu, Santosha Vardhana, and Michael L. Dustin
J Immunol 2008 181: 4852-4863. [Abstract] [Full Text] [PDF] Data Supplement  

Disruption of Allergenic Activity of the Major Grass Pollen Allergen Phl p 2 by Reassembly as a Mosaic Protein

Nadine Mothes-Luksch, Sabine Stumvoll, Birgit Linhart, Margit Focke, Marie-Therese Krauth, Alexander Hauswirth, Peter Valent, Petra Verdino, Tea Pavkov, Walter Keller, Monika Grote, and Rudolf Valenta
J Immunol 2008 181: 4864-4873. [Abstract] [Full Text] [PDF]  

IMMUNOGENETICS:

Large Scale Mass Spectrometric Profiling of Peptides Eluted from HLA Molecules Reveals N-Terminal-Extended Peptide Motifs

Hernando Escobar, David K. Crockett, Eduardo Reyes-Vargas, Andres Baena, Alan L. Rockwood, Peter E. Jensen, and Julio C. Delgado
J Immunol 2008 181: 4874-4882. [Abstract] [Full Text] [PDF] Data Supplement  

HOST DEFENSE:

The Pseudomonas Toxin Pyocyanin Inhibits the Dual Oxidase-Based Antimicrobial System as It Imposes Oxidative Stress on Airway Epithelial Cells

Balázs Rada, Kristen Lekstrom, Sorin Damian, Corinne Dupuy, and Thomas L. Leto
J Immunol 2008 181: 4883-4893. [Abstract] [Full Text] [PDF]  

The Varicellovirus UL49.5 Protein Blocks the Transporter Associated with Antigen Processing (TAP) by Inhibiting Essential Conformational Transitions in the 6+6 Transmembrane TAP Core Complex

Marieke C. Verweij, Danijela Koppers-Lalic, Sandra Loch, Florian Klauschies, Henri de la Salle, Edwin Quinten, Paul J. Lehner, Arend Mulder, Michael R. Knittler, Robert Tampé, Joachim Koch, Maaike E. Ressing, and Emmanuel J. H. J. Wiertz
J Immunol 2008 181: 4894-4907. [Abstract] [Full Text] [PDF]  

Type I IFNs Play a Role in Early Resistance, but Subsequent Susceptibility, to the African Trypanosomes

Rebecca Lopez, Karen P. Demick, John M. Mansfield, and Donna M. Paulnock
J Immunol 2008 181: 4908-4917. [Abstract] [Full Text] [PDF] Data Supplement  

CD8 T Cells Utilize TRAIL to Control Influenza Virus Infection

Erik L. Brincks, Arna Katewa, Tamara A. Kucaba, Thomas S. Griffith, and Kevin L. Legge
J Immunol 2008 181: 4918-4925. [Abstract] [Full Text] [PDF]  

Hepatitis C Virus Infection Sensitizes Human Hepatocytes to TRAIL-Induced Apoptosis in a Caspase 9-Dependent Manner

Lin Lan, Sebastian Gorke, Sibylle J. Rau, Mirjam B. Zeisel, Eberhard Hildt, Kiyoshi Himmelsbach, Monica Carvajal-Yepes, Roman Huber, Takaji Wakita, Annette Schmitt-Graeff, Cathy Royer, Hubert E. Blum, Richard Fischer, and Thomas F. Baumert
J Immunol 2008 181: 4926-4935. [Abstract] [Full Text] [PDF]  

Extracellular Gelsolin Binds Lipoteichoic Acid and Modulates Cellular Response to Proinflammatory Bacterial Wall Components

Robert Bucki, Fitzroy J. Byfield, Alina Kulakowska, Margaret E. McCormick, Wieslaw Drozdowski, Zbigniew Namiot, Thomas Hartung, and Paul A. Janmey
J Immunol 2008 181: 4936-4944. [Abstract] [Full Text] [PDF]  

Neutrophil Elastase Mediates Innate Host Protection against Pseudomonas aeruginosa

Tim O. Hirche, Rym Benabid, Gaetan Deslee, Sophie Gangloff, Samuel Achilefu, Moncef Guenounou, François Lebargy, Robert E. Hancock, and Azzaq Belaaouaj
J Immunol 2008 181: 4945-4954. [Abstract] [Full Text] [PDF]  

Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice

Emily K. Forbes, Clare Sander, Edward O. Ronan, Helen McShane, Adrian V. S. Hill, Peter C. L. Beverley, and Elma Z. Tchilian
J Immunol 2008 181: 4955-4964. [Abstract] [Full Text] [PDF]  

IL-17 Is a Critical Component of Vaccine-Induced Protection against Lung Infection by Lipopolysaccharide-Heterologous Strains of Pseudomonas aeruginosa

Gregory P. Priebe, Rebecca L. Walsh, Terra A. Cederroth, Akinobu Kamei, Yamara S. Coutinho-Sledge, Joanna B. Goldberg, and Gerald B. Pier
J Immunol 2008 181: 4965-4975. [Abstract] [Full Text] [PDF]  

Infection of Myeloid Dendritic Cells with Listeria monocytogenes Leads to the Suppression of T Cell Function by Multiple Inhibitory Mechanisms

Alexey Popov, Julia Driesen, Zeinab Abdullah, Claudia Wickenhauser, Marc Beyer, Svenja Debey-Pascher, Tomo Saric, Silke Kummer, Osamu Takikawa, Eugen Domann, Trinad Chakraborty, Martin Krönke, Olaf Utermöhlen, and Joachim L. Schultze
J Immunol 2008 181: 4976-4988. [Abstract] [Full Text] [PDF]  

Cathelicidin Administration Protects Mice from Bacillus anthracis Spore Challenge

Mark W. Lisanby, Melissa K. Swiecki, Brian L. P. Dizon, Kathryn J. Pflughoeft, Theresa M. Koehler, and John F. Kearney
J Immunol 2008 181: 4989-5000. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Mast Cells Promote Airway Smooth Muscle Cell Differentiation via Autocrine Up-Regulation of TGF-β1

Lucy Woodman, Salman Siddiqui, Glenn Cruse, Amanda Sutcliffe, Ruth Saunders, Davinder Kaur, Peter Bradding, and Christopher Brightling
J Immunol 2008 181: 5001-5007. [Abstract] [Full Text] [PDF]  

Platelet-Activating Factor Production in the Spinal Cord of Experimental Allergic Encephalomyelitis Mice via the Group IVA Cytosolic Phospholipase A₂-Lyso-PAFAT Axis

Yasuyuki Kihara, Keisuke Yanagida, Kayo Masago, Yoshihiro Kita, Daisuke Hishikawa, Hideo Shindou, Satoshi Ishii, and Takao Shimizu
J Immunol 2008 181: 5008-5014. [Abstract] [Full Text] [PDF]  

Calcium/Calmodulin-Dependent Protein Kinase (CaMK) IV Mediates Nucleocytoplasmic Shuttling and Release of HMGB1 during Lipopolysaccharide Stimulation of Macrophages

Xianghong Zhang, David Wheeler, Ying Tang, Lanping Guo, Richard A. Shapiro, Thomas J. Ribar, Anthony R. Means, Timothy R. Billiar, Derek C. Angus, and Matthew R. Rosengart
J Immunol 2008 181: 5015-5023. [Abstract] [Full Text] [PDF]  

Secretogranin III Directs Secretory Vesicle Biogenesis in Mast Cells in a Manner Dependent upon Interaction with Chromogranin A

Prerna Prasad, Angel A. Yanagihara, Andrea L. Small-Howard, Helen Turner, and Alexander J. Stokes
J Immunol 2008 181: 5024-5034. [Abstract] [Full Text] [PDF]  

Annexin A1 Regulates Intestinal Mucosal Injury, Inflammation, and Repair

Brian A. Babbin, Mike G. Laukoetter, Porfirio Nava, Stefan Koch, Winston Y. Lee, Christopher T. Capaldo, Eric Peatman, Eric A. Severson, Roderick J. Flower, Mauro Perretti, Charles A. Parkos, and Asma Nusrat
J Immunol 2008 181: 5035-5044. [Abstract] [Full Text] [PDF]  

IFN Consensus Sequence Binding Protein (Icsbp) Is Critical for Eosinophil Development

Maja Milanovic, Grzegorz Terszowski, Daniela Struck, Oliver Liesenfeld, and Dirk Carstanjen
J Immunol 2008 181: 5045-5053. [Abstract] [Full Text] [PDF]  

Immune Cell Activation by Enterotoxin Gene Cluster (egc)-Encoded and Non-egc Superantigens from Staphylococcus aureus

Dorothee Grumann, Sandra S. Scharf, Silva Holtfreter, Christian Kohler, Leif Steil, Susanne Engelmann, Michael Hecker, Uwe Völker, and Barbara M. Bröker
J Immunol 2008 181: 5054-5061. [Abstract] [Full Text] [PDF] Data Supplement  

STAT4 Isoforms Differentially Regulate Th1 Cytokine Production and the Severity of Inflammatory Bowel Disease

John T. O'Malley, Rajaraman D. Eri, Gretta L. Stritesky, Anubhav N. Mathur, Hua-Chen Chang, Harm HogenEsch, Mythily Srinivasan, and Mark H. Kaplan
J Immunol 2008 181: 5062-5070. [Abstract] [Full Text] [PDF]  

Evolution of the Inflammatory Response in Vertebrates: Fish TNF- Is a Powerful Activator of Endothelial Cells but Hardly Activates Phagocytes

Francisco J. Roca, Iván Mulero, Azucena López-Muñoz, Maria P. Sepulcre, Stephen A. Renshaw, José Meseguer, and Victoriano Mulero
J Immunol 2008 181: 5071-5081. [Abstract] [Full Text] [PDF]  

Prostaglandin E₂ Exerts Catabolic Effects in Osteoarthritis Cartilage: Evidence for Signaling via the EP4 Receptor

Mukundan Attur, Hayf E. Al-Mussawir, Jyoti Patel, Alison Kitay, Mandar Dave, Glyn Palmer, Michael H. Pillinger, and Steven B. Abramson
J Immunol 2008 181: 5082-5088. [Abstract] [Full Text] [PDF]  

Lipopolysaccharide-Induced Expression of Matrix Metalloproteinases in Human Monocytes Is Suppressed by IFN- via Superinduction of ATF-3 and Suppression of AP-1

Hao H. Ho, Taras T. Antoniv, Jong-Dae Ji, and Lionel B. Ivashkiv
J Immunol 2008 181: 5089-5097. [Abstract] [Full Text] [PDF]  

Lipoteichoic Acid Induces HO-1 Expression via the TLR2/MyD88/c-Src/NADPH Oxidase Pathway and Nrf2 in Human Tracheal Smooth Muscle Cells

I-Ta Lee, Shyi-Wu Wang, Chiang-Wen Lee, Chia-Chi Chang, Chih-Chung Lin, Shue-Fen Luo, and Chuen-Mao Yang
J Immunol 2008 181: 5098-5110. [Abstract] [Full Text] [PDF]  

Stimulatory Role of Lysophosphatidic Acid in Cyclooxygenase-2 Induction by Synovial Fluid of Patients with Rheumatoid Arthritis in Fibroblast-Like Synovial Cells

Hiromi Nochi, Hideaki Tomura, Masayuki Tobo, Nobuyuki Tanaka, Koichi Sato, Tetsuya Shinozaki, Tsutomu Kobayashi, Kenji Takagishi, Hideo Ohta, Fumikazu Okajima, and Koichi Tamoto
J Immunol 2008 181: 5111-5119. [Abstract] [Full Text] [PDF]  

Differential Production of IL-23 and IL-12 by Myeloid-Derived Dendritic Cells in Response to TLR Agonists

Robert E. Roses, Shuwen Xu, Min Xu, Ursula Koldovsky, Gary Koski, and Brian J. Czerniecki
J Immunol 2008 181: 5120-5127. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Requirements for Effective Antitumor Responses of TCR Transduced T Cells

Moniek A. de Witte, Annelies Jorritsma, Andrew Kaiser, Marly D. van den Boom, Maarten Dokter, Gavin M. Bendle, John B. A. G. Haanen, and Ton N. M. Schumacher
J Immunol 2008 181: 5128-5136. [Abstract] [Full Text] [PDF]  

Despite Biased TRBV Gene Usage against a Dominant HLA B57-Restricted Epitope, TCR Diversity Can Provide Recognition of Circulating Epitope Variants

Brenna C. Simons, Scott E. VanCompernolle, Rita M. Smith, Jie Wei, Louise Barnett, Shelly L. Lorey, Dirk Meyer-Olson, and Spyros A. Kalams
J Immunol 2008 181: 5137-5146. [Abstract] [Full Text] [PDF] Data Supplement  

Gene Expression Profiling in Autoimmune Noninfectious Uveitis Disease

Zhuqing Li, Baoying Liu, Arvydas Maminishkis, Sankaranarayana P. Mahesh, Steven Yeh, Julie Lew, Wee Kiak Lim, H. Nida Sen, Grace Clarke, Ronald Buggage, Sheldon S. Miller, and Robert B. Nussenblatt
J Immunol 2008 181: 5147-5157. [Abstract] [Full Text] [PDF]  

Human C3 Deficiency Associated with Impairments in Dendritic Cell Differentiation, Memory B Cells, and Regulatory T Cells

Arije Ghannam, Martine Pernollet, Jean-Luc Fauquert, Nicole Monnier, Denise Ponard, Marie-Bernadette Villiers, Josette Péguet-Navarro, Arlette Tridon, Joel Lunardi, Denis Gerlier, and Christian Drouet
J Immunol 2008 181: 5158-5166. [Abstract] [Full Text] [PDF]  

YKL-40 Is Elevated in Patients with Chronic Obstructive Pulmonary Disease and Activates Alveolar Macrophages

Séverine Létuvé, Alexander Kozhich, Nassim Arouche, Martine Grandsaigne, Jennifer Reed, Marie-Christine Dombret, Peter A. Kiener, Michel Aubier, Anthony J. Coyle, and Marina Pretolani
J Immunol 2008 181: 5167-5173. [Abstract] [Full Text] [PDF]  

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Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL

S. Kanswal, N. Katsenelson, A. Selvapandiyan, R. J. Bram, and M. Akkoyunlu
J Immunol 2008 181: 5174. [Full Text] [PDF]  

Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression

R. Noubade, N. Saligrama, K. Spach, R. Del Rio, E. P. Blankenhorn, T. Kantidakis, G. Milligan, M. Rincon, and C. Teuscher
J Immunol 2008 181: 5174. [Full Text] [PDF]  

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