IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2003 171: 4471-4472. [Full Text] [PDF]  

BRIEF REVIEWS:

Virus Evasion of MHC Class I Molecule Presentation

Jason L. Petersen, Chantey R. Morris, and Joyce C. Solheim
J Immunol 2003 171: 4473-4478. [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: Dendritic Cell Actin Cytoskeletal Polarization during Immunological Synapse Formation Is Highly Antigen-Dependent

Monther M. Al-Alwan, Robert S. Liwski, S. M. Mansour Haeryfar, William H. Baldridge, David W. Hoskin, Geoffrey Rowden, and Kenneth A. West
J Immunol 2003 171: 4479-4483. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Role of IL-12 Receptor 1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis

Guang-Xian Zhang, Shuo Yu, Bruno Gran, Jifen Li, Ines Siglienti, Xiaohan Chen, Divina Calida, Elvira Ventura, Malek Kamoun, and Abdolmohamad Rostami
J Immunol 2003 171: 4485-4492. [Abstract] [Full Text] [PDF]  

Interplay between TCR Affinity and Necessity of Coreceptor Ligation: High-Affinity Peptide-MHC/TCR Interaction Overcomes Lack of CD8 Engagement

Samantha E. Kerry, Jennifer Buslepp, Lorraine A. Cramer, Robert Maile, Lucinda L. Hensley, Alma I. Nielsen, Paula Kavathas, Barbara J. Vilen, Edward J. Collins, and Jeffrey A. Frelinger
J Immunol 2003 171: 4493-4503. [Abstract] [Full Text] [PDF]  

Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes

Emanuela Anastasi, Antonio F. Campese, Diana Bellavia, Angela Bulotta, Anna Balestri, Monica Pascucci, Saula Checquolo, Roberto Gradini, Urban Lendahl, Luigi Frati, Alberto Gulino, Umberto Di Mario, and Isabella Screpanti
J Immunol 2003 171: 4504-4511. [Abstract] [Full Text] [PDF]  

Thymocyte Sensitivity and Supramolecular Activation Cluster Formation Are Developmentally Regulated: A Partial Role for Sialylation

Timothy K. Starr, Mark A. Daniels, Michelle M. Lucido, Stephen C. Jameson, and Kristin A. Hogquist
J Immunol 2003 171: 4512-4520. [Abstract] [Full Text] [PDF]  

Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus

Jason Plotkin, Susan E. Prockop, Ana Lepique, and Howard T. Petrie
J Immunol 2003 171: 4521-4527. [Abstract] [Full Text] [PDF]  

CD8⁺⁺ T Cells That Lack Surface CD5 Antigen Expression Are a Major Lymphotactin (XCL1) Source in Peripheral Blood Lymphocytes

Laura Stievano, Valeria Tosello, Novella Marcato, Antonio Rosato, Annalisa Sebelin, Luigi Chieco-Bianchi, and Alberto Amadori
J Immunol 2003 171: 4528-4538. [Abstract] [Full Text] [PDF]  

Another View of T Cell Antigen Recognition: Cooperative Engagement of Glycolipid Antigens by Va14Ja18 Natural TCR

Aleksandar K. Stanic, R. Shashidharamurthy, Jelena S. Bezbradica, Naoto Matsuki, Yoshitaka Yoshimura, Sachiko Miyake, Eun Young Choi, Todd D. Schell, Luc Van Kaer, Satvir S. Tevethia, Derry C. Roopenian, Takashi Yamamura, and Sebastian Joyce
J Immunol 2003 171: 4539-4551. [Abstract] [Full Text] [PDF]  

Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program

Marcello Chieppa, Giancarlo Bianchi, Andrea Doni, Annalisa Del Prete, Marina Sironi, Gordana Laskarin, Paolo Monti, Lorenzo Piemonti, Andrea Biondi, Alberto Mantovani, Martino Introna, and Paola Allavena
J Immunol 2003 171: 4552-4560. [Abstract] [Full Text] [PDF]  

Translational Control of Inducible Nitric Oxide Synthase by IL-13 and Arginine Availability in Inflammatory Macrophages

Stefan El-Gayar, Heike Thüring-Nahler, Josef Pfeilschifter, Martin Röllinghoff, and Christian Bogdan
J Immunol 2003 171: 4561-4568. [Abstract] [Full Text] [PDF]  

Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide

Janet A. Willment, Hsi-Hsen Lin, Delyth M. Reid, Philip R. Taylor, David L. Williams, Simon Y. C. Wong, Siamon Gordon, and Gordon D. Brown
J Immunol 2003 171: 4569-4573. [Abstract] [Full Text] [PDF]  

Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells

Christian Blank, Ian Brown, Reinhard Marks, Hiroyuki Nishimura, Tasuku Honjo, and Thomas F. Gajewski
J Immunol 2003 171: 4574-4581. [Abstract] [Full Text] [PDF]  

Cell Proliferation Arrest within Intrathymic Lymphocyte Progenitor Cells Causes Thymic Atrophy Mediated by the Aryl Hydrocarbon Receptor

Michael D. Laiosa, Amber Wyman, Francis G. Murante, Nancy C. Fiore, J. Erin Staples, Thomas A. Gasiewicz, and Allen E. Silverstone
J Immunol 2003 171: 4582-4591. [Abstract] [Full Text] [PDF]  

Early Events in Peripheral Regulatory T Cell Induction via the Nasal Mucosa

Wendy W. J. Unger, Femke Hauet-Broere, Wendy Jansen, Lisette A. van Berkel, Georg Kraal, and Janneke N. Samsom
J Immunol 2003 171: 4592-4603. [Abstract] [Full Text] [PDF]  

CD4⁺CD25⁺ T Cells Lyse Antigen-Presenting B Cells by Fas-Fas Ligand Interaction in an Epitope-Specific Manner

Wim Janssens, Vincent Carlier, Bo Wu, Luc VanderElst, Marc G. Jacquemin, and Jean-Marie R. Saint-Remy
J Immunol 2003 171: 4604-4612. [Abstract] [Full Text] [PDF]  

A Murine Locus on Chromosome 18 Controls NKT Cell Homeostasis and Th Cell Differentiation

Feng Zhang, Zhiyan Liang, Naoto Matsuki, Luc Van Kaer, Sebastian Joyce, Edward K. Wakeland, and Thomas M. Aune
J Immunol 2003 171: 4613-4620. [Abstract] [Full Text] [PDF]  

CD40 Stimulation of Human Peripheral B Lymphocytes: Distinct Response from Naive and Memory Cells

Jessie F. Fecteau and Sonia Néron
J Immunol 2003 171: 4621-4629. [Abstract] [Full Text] [PDF]  

Ly49D Receptor Expressed on Immature B Cells Regulates Their IFN- Secretion, Actin Polymerization, and Homing

Gili Hart, Liat Flaishon, Shirly Becker-Herman, and Idit Shachar
J Immunol 2003 171: 4630-4638. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Estimating Hypermutation Rates from Clonal Tree Data

Steven H. Kleinstein, Yoram Louzoun, and Mark J. Shlomchik
J Immunol 2003 171: 4639-4649. [Abstract] [Full Text] [PDF]  

Genomic Organization and Expression Analysis of B7-H4, an Immune Inhibitory Molecule of the B7 Family

In-Hak Choi, Gefeng Zhu, Gabriel L. Sica, Scott E. Strome, John C. Cheville, Julie S. Lau, Yuwen Zhu, Dallas B. Flies, Koji Tamada, and Lieping Chen
J Immunol 2003 171: 4650-4654. [Abstract] [Full Text] [PDF]  

A Novel Interaction between Protein Kinase D and TNF Receptor-Associated Factor Molecules Regulates B Cell Receptor-CD40 Synergy

Sokol A. Haxhinasto and Gail A. Bishop
J Immunol 2003 171: 4655-4662. [Abstract] [Full Text] [PDF]  

Selection of Ig µ Heavy Chains by Complementarity-Determining Region 3 Length and Amino Acid Composition

Denise A. Martin, Harald Bradl, Tara J. Collins, Edith Roth, Hans-Martin Jäck, and Gillian E. Wu
J Immunol 2003 171: 4663-4671. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Silent Cleanup of Very Early Apoptotic Cells by Macrophages

Kahori Kurosaka, Munehisa Takahashi, Naoko Watanabe, and Yoshiro Kobayashi
J Immunol 2003 171: 4672-4679. [Abstract] [Full Text] [PDF]  

Infant and Adult Human B Cell Responses to Rotavirus Share Common Immunodominant Variable Gene Repertoires

Jörn-Hendrik Weitkamp, Nicole Kallewaard, Koichi Kusuhara, Elizabeth Bures, John V. Williams, Bonnie LaFleur, Harry B. Greenberg, and James E. Crowe, Jr.
J Immunol 2003 171: 4680-4688. [Abstract] [Full Text] [PDF] Data Supplement  

CD4⁺ T Cells Mediate IFN--Independent Control of Mycobacterium tuberculosis Infection Both In Vitro and In Vivo

Siobhán C. Cowley and Karen L. Elkins
J Immunol 2003 171: 4689-4699. [Abstract] [Full Text] [PDF]  

TNF--Dependent ICAM-1- and VCAM-1-Mediated Inflammatory Responses Are Delayed in Neonatal Mice Infected with Pneumocystis carinii

Mahboob H. Qureshi, Joan Cook-Mills, Dennis E. Doherty, and Beth A. Garvy
J Immunol 2003 171: 4700-4707. [Abstract] [Full Text] [PDF]  

IL-4 Suppresses the Expression and the Replication of Hepatitis B Virus in the Hepatocellular Carcinoma Cell Line Hep3B

Sue-Jane Lin, Pei-Yun Shu, Chungming Chang, Ah-Kau Ng, and Cheng-po Hu
J Immunol 2003 171: 4708-4716. [Abstract] [Full Text] [PDF]  

M Cell DNA Vaccination for CTL Immunity to HIV

Xinhai Wang, David M. Hone, Asmahan Haddad, Mohamed T. Shata, and David W. Pascual
J Immunol 2003 171: 4717-4725. [Abstract] [Full Text] [PDF]  

Th1 Cell-Mediated Resistance to Cutaneous Infection with Leishmania major Is Independent of P- and E-Selectins

Colby Zaph and Phillip Scott
J Immunol 2003 171: 4726-4732. [Abstract] [Full Text] [PDF]  

Deficient CD4⁺ T Cell Priming and Regression of CD8⁺ T Cell Functionality in Virus-Infected Mice Lacking a Normal B Cell Compartment

Jan Pravsgaard Christensen, Susanne Ørding Kauffmann, and Allan Randrup Thomsen
J Immunol 2003 171: 4733-4741. [Abstract] [Full Text] [PDF]  

An Inclusion Membrane Protein from Chlamydia trachomatis Enters the MHC Class I Pathway and Stimulates a CD8⁺ T Cell Response

Michael N. Starnbach, Wendy P. Loomis, Pam Ovendale, David Regan, Bruce Hess, Mark R. Alderson, and Steven P. Fling
J Immunol 2003 171: 4742-4749. [Abstract] [Full Text] [PDF]  

Innate Inhibition of Adaptive Immunity: Mycobacterium tuberculosis-Induced IL-6 Inhibits Macrophage Responses to IFN-

Vijaya Nagabhushanam, Alejandra Solache, Li-Min Ting, Claire J. Escaron, Jennifer Y. Zhang, and Joel D. Ernst
J Immunol 2003 171: 4750-4757. [Abstract] [Full Text] [PDF]  

Mice Lacking Myeloid Differentiation Factor 88 Display Profound Defects in Host Resistance and Immune Responses to Mycobacterium avium Infection Not Exhibited by Toll-Like Receptor 2 (TLR2)- and TLR4-Deficient Animals

Carl G. Feng, Charles A. Scanga, Carmen M. Collazo-Custodio, Allen W. Cheever, Sara Hieny, Patricia Caspar, and Alan Sher
J Immunol 2003 171: 4758-4764. [Abstract] [Full Text] [PDF]  

IL-10 Mediates Suppression of the CD8 T Cell IFN- Response to a Novel Viral Epitope in a Primed Host

Xiao Song Liu, Yan Xu, Lani Hardy, Vithagna Khammanivong, Weiming Zhao, Germain J. P. Fernando, Graham R. Leggatt, and Ian H. Frazer
J Immunol 2003 171: 4765-4772. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Inhibition of Neutrophil Leukotriene B₄ Production by a Novel Synthetic N-3 Polyunsaturated Fatty Acid Analogue, -Oxa 21:3n-3

Brenton S. Robinson, Deborah A. Rathjen, Neil A. Trout, Christopher J. Easton, and Antonio Ferrante
J Immunol 2003 171: 4773-4779. [Abstract] [Full Text] [PDF]  

CpG-Containing Oligodeoxynucleotide 1826 Converts the Weak Uveitogenic Rat Interphotoreceptor Retinoid-Binding Protein Peptide 1181–1191 into a Strong Uveitogen

Hui Shao, Song Lei, Sheher L. Sun, Jim Xiang, Henry J. Kaplan, and Deming Sun
J Immunol 2003 171: 4780-4785. [Abstract] [Full Text] [PDF]  

Complement Regulatory Protein C1 Inhibitor Binds to Selectins and Interferes with Endothelial-Leukocyte Adhesion

Shenghe Cai and Alvin E. Davis, III
J Immunol 2003 171: 4786-4791. [Abstract] [Full Text] [PDF]  

Novel and Detrimental Effects of Lipopolysaccharide on In Vitro Generation of Immature Dendritic Cells: Involvement of Mitogen-Activated Protein Kinase p38

Jin Xie, Jianfei Qian, Siqing Wang, Muta E. Freeman, III, Joshua Epstein, and Qing Yi
J Immunol 2003 171: 4792-4800. [Abstract] [Full Text] [PDF]  

In Vivo Impairment of Neutrophil Recruitment during Lentivirus Infection

Paul Kubes, Bryan Heit, Guido van Marle, James B. Johnston, Derrice Knight, Adil Khan, and Christopher Power
J Immunol 2003 171: 4801-4808. [Abstract] [Full Text] [PDF]  

Nitric Oxide Regulation of Human Peripheral Blood Mononuclear Cells: Critical Time Dependence and Selectivity for Cytokine versus Chemokine Expression

Sarah E. Macphail, Claire A. Gibney, Bernadette M. Brooks, C. George Booth, Brian F. Flanagan, and John W. Coleman
J Immunol 2003 171: 4809-4815. [Abstract] [Full Text] [PDF]  

The Phenotype of Inflammatory Macrophages Is Stimulus Dependent: Implications for the Nature of the Inflammatory Response

Andrew D. Cook, Emma L. Braine, and John A. Hamilton
J Immunol 2003 171: 4816-4823. [Abstract] [Full Text] [PDF]  

DNA Vaccination Against Specific Pathogenic TCRs Reduces Proteinuria in Active Heymann Nephritis by Inducing Specific Autoantibodies

Huiling Wu, Giles Walters, John F. Knight, and Stephen I. Alexander
J Immunol 2003 171: 4824-4829. [Abstract] [Full Text] [PDF]  

IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells

Kristiana Kandere-Grzybowska, Richard Letourneau, Duraisamy Kempuraj, Jill Donelan, Sarah Poplawski, William Boucher, Achilles Athanassiou, and Theoharis C. Theoharides
J Immunol 2003 171: 4830-4836. [Abstract] [Full Text] [PDF]  

Short-Time Infusion of Fish Oil-Based Lipid Emulsions, Approved for Parenteral Nutrition, Reduces Monocyte Proinflammatory Cytokine Generation and Adhesive Interaction with Endothelium in Humans

Konstantin Mayer, Sandra Meyer, Marion Reinholz-Muhly, Ulrich Maus, Martina Merfels, Jürgen Lohmeyer, Friedrich Grimminger, and Werner Seeger
J Immunol 2003 171: 4837-4843. [Abstract] [Full Text] [PDF]  

Role of CXCL9/CXCR3 Chemokine Biology during Pathogenesis of Acute Lung Allograft Rejection

John A. Belperio, Michael P. Keane, Marie D. Burdick, Joseph P. Lynch, III, David A. Zisman, Ying Ying Xue, Kewang Li, Abbas Ardehali, David J. Ross, and Robert M. Strieter
J Immunol 2003 171: 4844-4852. [Abstract] [Full Text] [PDF]  

Blockade of Vascular Endothelial Growth Factor Receptor I (VEGF-RI), but not VEGF-RII, Suppresses Joint Destruction in the K/BxN Model of Rheumatoid Arthritis

Michel De Bandt, Meriem H. Ben Mahdi, Véronique Ollivier, Maggy Grossin, Magali Dupuis, Murielle Gaudry, Peter Bohlen, Kenneth E. Lipson, Audie Rice, Yan Wu, Marie-Anne Gougerot-Pocidalo, and Catherine Pasquier
J Immunol 2003 171: 4853-4859. [Abstract] [Full Text] [PDF]  

Accumulation of Peribronchial Mast Cells in a Mouse Model of Ovalbumin Allergen Induced Chronic Airway Inflammation: Modulation by Immunostimulatory DNA Sequences

Reid K. Ikeda, Marina Miller, Jyothi Nayar, Linda Walker, Jae Youn Cho, Kirsti McElwain, Shauna McElwain, Eyal Raz, and David H. Broide
J Immunol 2003 171: 4860-4867. [Abstract] [Full Text] [PDF]  

Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease

Giorgos Bamias, Charles Martin, III, Marco Marini, Sharon Hoang, Margarita Mishina, William G. Ross, Muhammadreza A. Sachedina, Charles M. Friel, James Mize, Stephen J. Bickston, Theresa T. Pizarro, Ping Wei, and Fabio Cominelli
J Immunol 2003 171: 4868-4874. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

CC Chemokine Receptor 2 Expression in Donor Cells Serves an Essential Role in Graft-versus-Host-Disease

Arun R. Rao, Marlon P. Quinones, Edgar Garavito, Yogeshwar Kalkonde, Fabio Jimenez, Caroline Gibbons, Jennifer Perez, Peter Melby, William Kuziel, Robert L. Reddick, Sunil K. Ahuja, and Seema S. Ahuja
J Immunol 2003 171: 4875-4885. [Abstract] [Full Text] [PDF]  

Transcriptional Regulation of Type I Diabetes by NF-B

Salah-Eddine Lamhamedi-Cherradi, Shijun Zheng, Brendan A. Hilliard, Lingyun Xu, Jing Sun, Saaib Alsheadat, Hsiou-Chi Liou, and Youhai H. Chen
J Immunol 2003 171: 4886-4892. [Abstract] [Full Text] [PDF]  

Polyclonal CTL Responses Observed in Melanoma Patients Vaccinated with Dendritic Cells Pulsed with a MAGE-3.A1 Peptide

Danièle Godelaine, Javier Carrasco, Sophie Lucas, Vaios Karanikas, Beatrice Schuler-Thurner, Pierre G. Coulie, Gerold Schuler, Thierry Boon, and Aline Van Pel
J Immunol 2003 171: 4893-4897. [Abstract] [Full Text] [PDF]  

Monoclonal Anti-MAGE-3 CTL Responses in Melanoma Patients Displaying Tumor Regression after Vaccination with a Recombinant Canarypox Virus

Vaios Karanikas, Christophe Lurquin, Didier Colau, Nicolas van Baren, Charles De Smet, Bernard Lethé, Thierry Connerotte, Véronique Corbière, Marie-Ange Demoitié, Danielle Liénard, Brigitte Dréno, Thierry Velu, Thierry Boon, and Pierre G. Coulie
J Immunol 2003 171: 4898-4904. [Abstract] [Full Text] [PDF]  

Antibodies to Keyhole Limpet Hemocyanin Cross-React with an Epitope on the Polysaccharide Capsule of Cryptococcus neoformans and Other Carbohydrates: Implications for Vaccine Development

Rena J. May, David O. Beenhouwer, and Matthew D. Scharff
J Immunol 2003 171: 4905-4912. [Abstract] [Full Text] [PDF]  

Gene Transfer of a Cell Cycle Modulator Exerts Anti-Inflammatory Effects in the Treatment of Arthritis

Yoshinori Nonomura, Hitoshi Kohsaka, Kenji Nagasaka, and Nobuyuki Miyasaka
J Immunol 2003 171: 4913-4919. [Abstract] [Full Text] [PDF]  

An Immunomodulatory GpG Oligonucleotide for the Treatment of Autoimmunity via the Innate and Adaptive Immune Systems

Peggy P. Ho, Paulo Fontoura, Pedro J. Ruiz, Lawrence Steinman, and Hideki Garren
J Immunol 2003 171: 4920-4926. [Abstract] [Full Text] [PDF]  

Thymic CD8⁺ T Cell Production Strongly Influences Tumor Antigen Recognition and Age-Dependent Glioma Mortality

Christopher J. Wheeler, Keith L. Black, Gentao Liu, Han Ying, John S. Yu, Wenxuan Zhang, and Paul K. Lee
J Immunol 2003 171: 4927-4933. [Abstract] [Full Text] [PDF]  

CORRECTIONS:

Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice

Alfred R. Oliver, Geoffrey M. Lyon, and Nancy H. Ruddle
J Immunol 2003 171: 4934. [Full Text] [PDF]  

Coevolution of Markers of Innate and Adaptive Immunity in Skin and Peripheral Blood of Patients with Erythema Migrans

Juan C. Salazar, Constance D. Pope, Timothy J. Sellati, Henry M. Feder, Jr., Thomas G. Kiely, Kenneth R. Dardick, Ronald L. Buckman, Meagan W. Moore, Melissa J. Caimano, Jonathan G. Pope, Peter J. Krause, and Justin D. Radolf
J Immunol 2003 171: 4934. [Full Text] [PDF]  

Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells

Misako Matsumoto, Kenji Funami, Masako Tanabe, Hiroyuki Oshiumi, Masashi Shingai, Yoshiyuki Seto, Akitsugu Yamamoto, and Tsukasa Seya
J Immunol 2003 171: 4934. [Full Text] [PDF]  

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