IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2003 170: 4423-4424. [Full Text] [PDF]  

LETTERS TO THE EDITOR:

CIITA Expression and Th1-Th2 Balance

Cheong-Hee Chang, Tania Gourley, Dipak Patel, Luc A. Otten, Walter Reith, and Hans Acha-Orbea
J Immunol 2003 170: 4425. [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: CD8⁺ Effector T Cells Reject Tumors by Direct Antigen Recognition but Indirect Action on Host Cells

Thomas Schüler and Thomas Blankenstein
J Immunol 2003 170: 4427-4431. [Abstract] [Full Text] [PDF]  

Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to Klebsiella pneumoniae Infection

Kyle I. Happel, Mingquan Zheng, Erana Young, Lee J. Quinton, Euan Lockhart, Alistair J. Ramsay, Judd E. Shellito, Jill R. Schurr, Gregory J. Bagby, Steve Nelson, and Jay K. Kolls
J Immunol 2003 170: 4432-4436. [Abstract] [Full Text] [PDF]  

Cutting Edge: Conventional CD8⁺ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-1

Christopher M. Smith, Gabrielle T. Belz, Nicholas S. Wilson, Jose A. Villadangos, Ken Shortman, Francis R. Carbone, and William R. Heath
J Immunol 2003 170: 4437-4440. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

A Pyrazole Derivative, YM-58483, Potently Inhibits Store-Operated Sustained Ca²⁺ Influx and IL-2 Production in T Lymphocytes

Jun Ishikawa, Keiko Ohga, Taiji Yoshino, Ryuichi Takezawa, Atsushi Ichikawa, Hirokazu Kubota, and Toshimitsu Yamada
J Immunol 2003 170: 4441-4449. [Abstract] [Full Text] [PDF]  

Decorin Reverses the Repressive Effect of Autocrine-Produced TGF- on Mouse Macrophage Activation

Mònica Comalada, Marina Cardó, Jordi Xaus, Annabel F. Valledor, Jorge Lloberas, Francesc Ventura, and Antonio Celada
J Immunol 2003 170: 4450-4456. [Abstract] [Full Text] [PDF]  

IL-6 Production by Pulmonary Dendritic Cells Impedes Th1 Immune Responses

Ingrid L. Dodge, Michelle Woldemar Carr, Manuela Cernadas, and Michael B. Brenner
J Immunol 2003 170: 4457-4464. [Abstract] [Full Text] [PDF]  

Activation with CpG-A and CpG-B Oligonucleotides Reveals Two Distinct Regulatory Pathways of Type I IFN Synthesis in Human Plasmacytoid Dendritic Cells

Miren Kerkmann, Simon Rothenfusser, Veit Hornung, Andreas Towarowski, Moritz Wagner, Anja Sarris, Thomas Giese, Stefan Endres, and Gunther Hartmann
J Immunol 2003 170: 4465-4474. [Abstract] [Full Text] [PDF]  

Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio

Luis Rodríguez-Borlado, Domingo F. Barber, Carmen Hernández, Miguel A. Rodríguez-Marcos, Arsenio Sánchez, Emilio Hirsch, Matthias Wymann, Carlos Martínez-A., and Ana C. Carrera
J Immunol 2003 170: 4475-4482. [Abstract] [Full Text] [PDF]  

Glatiramer Acetate (Copolymer-1, Copaxone) Promotes Th2 Cell Development and Increased IL-10 Production Through Modulation of Dendritic Cells

Pedro L. Vieira, Heleen C. Heystek, Jan Wormmeester, Eddy A. Wierenga, and Martien L. Kapsenberg
J Immunol 2003 170: 4483-4488. [Abstract] [Full Text] [PDF]  

Distinct Pathways for NF-B Regulation Are Associated with Aberrant Macrophage IL-12 Production in Lupus- and Diabetes-Prone Mouse Strains

Jiajian Liu and David I. Beller
J Immunol 2003 170: 4489-4496. [Abstract] [Full Text] [PDF]  

Determinants of Human B Cell Migration Across Brain Endothelial Cells

Andrea Alter, Martin Duddy, Sherry Hebert, Katarzyna Biernacki, Alexandre Prat, Jack P. Antel, Voon Wee Yong, Robert K. Nuttall, Caroline J. Pennington, Dylan R. Edwards, and Amit Bar-Or
J Immunol 2003 170: 4497-4505. [Abstract] [Full Text] [PDF]  

Homology Between an Alloantigen and a Self MHC Allele Calibrates the Avidity of the Alloreactive T Cell Repertoire Independent of TCR Affinity

Tara M. C. Hornell, Nancy Myers, Ted H. Hansen, and Janet M. Connolly
J Immunol 2003 170: 4506-4514. [Abstract] [Full Text] [PDF]  

Correction of Defects Responsible for Impaired Qa-2 Class Ib MHC Expression on Melanoma Cells Protects Mice from Tumor Growth

Eugene Y. Chiang, Maile Henson, and Iwona Stroynowski
J Immunol 2003 170: 4515-4523. [Abstract] [Full Text] [PDF]  

IL-7-Regulated Homeostatic Maintenance of Recent Thymic Emigrants in Association with Caspase-Mediated Cell Proliferation and Apoptotic Cell Death

Rose M. O’Neill, Jaythoon Hassan, and Denis J. Reen
J Immunol 2003 170: 4524-4531. [Abstract] [Full Text] [PDF]  

Study of the Mechanism of TCR Antagonism Using Dual-TCR-Expressing T Cells

Wen Yang and Howard M. Grey
J Immunol 2003 170: 4532-4538. [Abstract] [Full Text] [PDF]  

Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP-2) Can Play a Direct Role in the Inhibitory Function of Killer Cell Ig-Like Receptors in Human NK Cells

Sei-ichi Yusa and Kerry S. Campbell
J Immunol 2003 170: 4539-4547. [Abstract] [Full Text] [PDF]  

Murine Neonatal Lymphocytes Show Rapid Early Cell Cycle Entry and Cell Division

Becky Adkins, Tonya Williamson, Patricia Guevara, and Yurong Bu
J Immunol 2003 170: 4548-4556. [Abstract] [Full Text] [PDF]  

Allelic Exclusion of the TCR -Chain Is an Active Process Requiring TCR-Mediated Signaling and c-Cbl

Nathalie Niederberger, Kaisa Holmberg, S. Munir Alam, Wayne Sakati, Mayumi Naramura, Hua Gu, and Nicholas R. J. Gascoigne
J Immunol 2003 170: 4557-4563. [Abstract] [Full Text] [PDF]  

B1 Cells Contribute to Serum IgM, But Not to Intestinal IgA, Production in Gnotobiotic Ig Allotype Chimeric Mice

M. Christine Thurnheer, Adrian W. Zuercher, John J. Cebra, and Nicolaas A. Bos
J Immunol 2003 170: 4564-4571. [Abstract] [Full Text] [PDF]  

TGF-1 Suppresses Myeloid Fc Receptor Function by Regulating the Expression and Function of the Common -Subunit

Susheela Tridandapani, Richard Wardrop, Christopher P. Baran, Yijie Wang, Judy M. Opalek, Michael A. Caligiuri, and Clay B. Marsh
J Immunol 2003 170: 4572-4577. [Abstract] [Full Text] [PDF]  

The Cyclopentenone-Type Prostaglandin 15-Deoxy-^12,14-Prostaglandin J₂ Inhibits CD95 Ligand Gene Expression in T Lymphocytes: Interference with Promoter Activation Via Peroxisome Proliferator-Activated Receptor--Independent Mechanisms

Marco Cippitelli, Cinzia Fionda, Danilo Di Bona, Aldo Lupo, Mario Piccoli, Luigi Frati, and Angela Santoni
J Immunol 2003 170: 4578-4592. [Abstract] [Full Text] [PDF]  

Enforced bcl-x_L Gene Expression Restored Splenic B Lymphocyte Development in BAFF-R Mutant Mice

Ian J. Amanna, Jennifer P. Dingwall, and Colleen E. Hayes
J Immunol 2003 170: 4593-4600. [Abstract] [Full Text] [PDF]  

Influenza A Virus Infection Inhibits the Efficient Recruitment of Th2 Cells into the Airways and the Development of Airway Eosinophilia

Gisela Wohlleben, Justus Müller, Ursula Tatsch, Christine Hambrecht, Udo Herz, Harald Renz, Edgar Schmitt, Heidrun Moll, and Klaus J. Erb
J Immunol 2003 170: 4601-4611. [Abstract] [Full Text] [PDF]  

TGF-1 Regulates Lymphocyte Homeostasis by Preventing Activation and Subsequent Apoptosis of Peripheral Lymphocytes

Ramireddy Bommireddy, Vijay Saxena, Ilona Ormsby, Moying Yin, Gregory P. Boivin, George F. Babcock, Ram R. Singh, and Thomas Doetschman
J Immunol 2003 170: 4612-4622. [Abstract] [Full Text] [PDF]  

CD5 Inhibits Signaling at the Immunological Synapse Without Impairing Its Formation

Cédric Brossard, Monique Semichon, Alain Trautmann, and Georges Bismuth
J Immunol 2003 170: 4623-4629. [Abstract] [Full Text] [PDF] Data Supplement  

IKK Is Required for Peripheral B Cell Survival and Proliferation

Zhi-Wei Li, Sidne A. Omori, Tord Labuda, Michael Karin, and Robert C. Rickert
J Immunol 2003 170: 4630-4637. [Abstract] [Full Text] [PDF]  

Naive T Cell Recruitment to Nonlymphoid Tissues: A Role for Endothelium-Expressed CC Chemokine Ligand 21 in Autoimmune Disease and Lymphoid Neogenesis

Wolfgang Weninger, Hege S. Carlsen, Mahmoud Goodarzi, Farzad Moazed, Maura A. Crowley, Espen S. Baekkevold, Lois L. Cavanagh, and Ulrich H. von Andrian
J Immunol 2003 170: 4638-4648. [Abstract] [Full Text] [PDF]  

A Role of CXC Chemokine Ligand 12/Stromal Cell-Derived Factor-1/Pre-B Cell Growth Stimulating Factor and Its Receptor CXCR4 in Fetal and Adult T Cell Development in Vivo

Toshiaki Ara, Manami Itoi, Kenji Kawabata, Takeshi Egawa, Koji Tokoyoda, Tatsuki Sugiyama, Nobutaka Fujii, Takashi Amagai, and Takashi Nagasawa
J Immunol 2003 170: 4649-4655. [Abstract] [Full Text] [PDF]  

Maternal Autoantibody Triggers De Novo T Cell-Mediated Neonatal Autoimmune Disease

Yulius Y. Setiady, Eileen T. Samy, and Kenneth S. K. Tung
J Immunol 2003 170: 4656-4664. [Abstract] [Full Text] [PDF]  

Endogenous IL-17 as a Mediator of Neutrophil Recruitment Caused by Endotoxin Exposure in Mouse Airways

Masahide Miyamoto, Olof Prause, Margareta Sjöstrand, Martti Laan, Jan Lötvall, and Anders Lindén
J Immunol 2003 170: 4665-4672. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

The Paradox of Immune Molecular Recognition of -Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for TCRs

Carlos Cantu, III, Kamel Benlagha, Paul B. Savage, Albert Bendelac, and Luc Teyton
J Immunol 2003 170: 4673-4682. [Abstract] [Full Text] [PDF]  

Point Mutations in or Near the Antigen-Binding Groove of HLA-DR3 Implicate Class II-Associated Invariant Chain Peptide Affinity as a Constraint on MHC Class II Polymorphism

Robert C. Doebele, Achal Pashine, Wendy Liu, Dennis M. Zaller, Michael Belmares, Robert Busch, and Elizabeth D. Mellins
J Immunol 2003 170: 4683-4692. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Absence of CC Chemokine Ligand 2 Results in an Altered Th1/Th2 Cytokine Balance and Failure to Expel Trichuris muris Infection

Matthew L. deSchoolmeester, Matthew C. Little, Barrett J. Rollins, and Kathryn J. Else
J Immunol 2003 170: 4693-4700. [Abstract] [Full Text] [PDF]  

Origin of Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 and MASP-3 Involved in the Lectin Complement Pathway Traced Back to the Invertebrate, Amphioxus

Yuichi Endo, Masaru Nonaka, Hidetoshi Saiga, Yuji Kakinuma, Akiko Matsushita, Minoru Takahashi, Misao Matsushita, and Teizo Fujita
J Immunol 2003 170: 4701-4707. [Abstract] [Full Text] [PDF]  

Retrocyclin, an Antiretroviral -Defensin, Is a Lectin

Wei Wang, Alexander M. Cole, Teresa Hong, Alan J. Waring, and Robert I. Lehrer
J Immunol 2003 170: 4708-4716. [Abstract] [Full Text] [PDF]  

CpG Oligodeoxynucleotides Protect Normal and SIV-Infected Macaques from Leishmania Infection

Daniela Verthelyi, Mayda Gursel, Richard T. Kenney, Jeffrey D. Lifson, Shuying Liu, Joan Mican, and Dennis M. Klinman
J Immunol 2003 170: 4717-4723. [Abstract] [Full Text] [PDF]  

IL-1 Receptor Type 1 Gene-Deficient Mice Demonstrate an Impaired Host Defense Against Pneumococcal Meningitis

Petra J. G. Zwijnenburg, Tom van der Poll, Sandrine Florquin, John J. Roord, and A. Marceline van Furth
J Immunol 2003 170: 4724-4730. [Abstract] [Full Text] [PDF]  

IL-12 Receptor 1 and Toll-Like Receptor 4 Increase IL-1- and IL-18-Associated Myocarditis and Coxsackievirus Replication

DeLisa Fairweather, Susan Yusung, Sylvia Frisancho, Masheka Barrett, Shannon Gatewood, Ronelle Steele, and Noel R. Rose
J Immunol 2003 170: 4731-4737. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E₂ Production in the Rat Adjuvant-Induced Arthritis Model

David Claveau, Mirna Sirinyan, Jocelyne Guay, Robert Gordon, Chi-Chung Chan, Yves Bureau, Denis Riendeau, and Joseph A. Mancini
J Immunol 2003 170: 4738-4744. [Abstract] [Full Text] [PDF]  

Mitochondrial Potential and Reactive Oxygen Intermediates in Antigen-Specific CD8⁺ T Cells During Viral Infection

Jason M. Grayson, Nathan G. Laniewski, J. Gibson Lanier, and Rafi Ahmed
J Immunol 2003 170: 4745-4751. [Abstract] [Full Text] [PDF]  

¹²-Prostaglandin J₂, a Plasma Metabolite of Prostaglandin D₂, Causes Eosinophil Mobilization from the Bone Marrow and Primes Eosinophils for Chemotaxis

Akos Heinemann, Rufina Schuligoi, Ian Sabroe, Adele Hartnell, and Bernhard A. Peskar
J Immunol 2003 170: 4752-4758. [Abstract] [Full Text] [PDF]  

IL-1-Driven Endogenous IL-10 Production Protects Against the Systemic and Local Acute Inflammatory Response Following Intestinal Reperfusion Injury

Danielle G. Souza, Rodrigo Guabiraba, Vanessa Pinho, Adrian Bristow, Stephen Poole, and Mauro M. Teixeira
J Immunol 2003 170: 4759-4766. [Abstract] [Full Text] [PDF]  

Tyrosine Phosphorylation of I-B Kinase / by Protein Kinase C-Dependent c-Src Activation Is Involved in TNF--Induced Cyclooxygenase-2 Expression

Wei-Chien Huang, Jun-Jie Chen, Hiroyasu Inoue, and Ching-Chow Chen
J Immunol 2003 170: 4767-4775. [Abstract] [Full Text] [PDF]  

IFN- Gene Deletion Leads to Augmented and Chronic Demyelinating Experimental Autoimmune Encephalomyelitis

Ingrid Teige, Alexandra Treschow, Anna Teige, Ragnar Mattsson, Vaidrius Navikas, Tomas Leanderson, Rikard Holmdahl, and Shohreh Issazadeh-Navikas
J Immunol 2003 170: 4776-4784. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Necroinflammatory Liver Disease in BALB/c Background, TGF-1-Deficient Mice Requires CD4⁺ T Cells

Lynnie A. Rudner, Jack T. Lin, Il-Kyoo Park, Justin M. M. Cates, Darci A. Dyer, Douglas M. Franz, Margaret A. French, Elizabeth M. Duncan, Hillary D. White, and James D. Gorham
J Immunol 2003 170: 4785-4792. [Abstract] [Full Text] [PDF]  

Albumin-Based Drug Delivery as Novel Therapeutic Approach for Rheumatoid Arthritis

Andreas Wunder, Ulf Müller-Ladner, Ernst H. K. Stelzer, Jürgen Funk, Elena Neumann, Gerd Stehle, Thomas Pap, Hannsjörg Sinn, Steffen Gay, and Christoph Fiehn
J Immunol 2003 170: 4793-4801. [Abstract] [Full Text] [PDF]  

Transfer of Severe Experimental Autoimmune Encephalomyelitis by IL-12- and IL-18-Potentiated T Cells Is Estrogen Sensitive

Atsushi Ito, Agata Matejuk, Corwyn Hopke, Heather Drought, Jami Dwyer, Alex Zamora, Sandhya Subramanian, Arthur A. Vandenbark, and Halina Offner
J Immunol 2003 170: 4802-4809. [Abstract] [Full Text] [PDF]  

CC Chemokine Ligand 1 Promotes Recruitment of Eosinophils But Not Th2 Cells During the Development of Allergic Airways Disease

Benjamin Bishop and Clare M. Lloyd
J Immunol 2003 170: 4810-4817. [Abstract] [Full Text] [PDF]  

Differential Contribution of IL-4 and STAT6 vs STAT4 to the Development of Lupus Nephritis

Ram Raj Singh, Vijay Saxena, Song Zang, Lily Li, Fred D. Finkelman, David P. Witte, and Chaim O. Jacob
J Immunol 2003 170: 4818-4825. [Abstract] [Full Text] [PDF]  

The Naive B Cell Repertoire Predisposes to Antigen-Induced Systemic Lupus Erythematosus

Chuansheng Wang, Magi Khalil, Jeffrey Ravetch, and Betty Diamond
J Immunol 2003 170: 4826-4832. [Abstract] [Full Text] [PDF]  

Inhibition of IFN- Signaling by Glucocorticoids

Xiaoyu Hu, Wai-Ping Li, Charis Meng, and Lionel B. Ivashkiv
J Immunol 2003 170: 4833-4839. [Abstract] [Full Text] [PDF]  

Phosphatidylserine on HIV Envelope Is a Cofactor for Infection of Monocytic Cells

Melissa K. Callahan, Paul M. Popernack, Shigeki Tsutsui, Linh Truong, Robert A. Schlegel, and Andrew J. Henderson
J Immunol 2003 170: 4840-4845. [Abstract] [Full Text] [PDF]  

Complementarity-Determining Region 3 Spectratyping Analysis of the TCR Repertoire in Multiple Sclerosis

Yoh Matsumoto, Wong Kee Yoon, Youngheun Jee, Kazuo Fujihara, Tatsuro Misu, Shigeru Sato, Ichiro Nakashima, and Yasuto Itoyama
J Immunol 2003 170: 4846-4853. [Abstract] [Full Text] [PDF]  

Design, Construction, and In Vitro Analyses of Multivalent Antibodies

Kathy Miller, Gloria Meng, Jun Liu, Amy Hurst, Vanessa Hsei, Wai-Lee Wong, Rene Ekert, David Lawrence, Steven Sherwood, Laura DeForge, Jacques Gaudreault, Gilbert Keller, Mark Sliwkowski, Avi Ashkenazi, and Leonard Presta
J Immunol 2003 170: 4854-4861. [Abstract] [Full Text] [PDF]  

Cryptic CTL Epitope on a Murine Sarcoma Meth A Generated by Exon Extension as a Novel Mechanism

Akiko Uenaka, Yoshiki Hirano, Hidenori Hata, Sanda Win, Toshiki Aji, Motoyuki Tanaka, Toshiro Ono, Jonathan C. A. Skipper, Kenji Shimizu, and Eiichi Nakayama
J Immunol 2003 170: 4862-4868. [Abstract] [Full Text] [PDF]  

CORRECTIONS:

Microsatallite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis

Sang-Heon Lee, Dong Kyung Chang, Ajay Goel, C. Richard Boland, William Bugbee, David L. Boyle, and Gary S. Firestein
J Immunol 2003 170: 4869. [Full Text] [PDF]  

A Single Polymorphic Residue Within the Peptide-Binding Cleft of MHC Class I Molecules Determines Spectrum of Tapasin Dependence

Boyoun Park, Sungwook Lee, Euijae Kim, and Kwangseog Ahn
J Immunol 2003 170: 4869. [Full Text] [PDF]  

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