IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2003 170: 665-666. [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: Proliferating Fibroblasts Respond to Collagenous C1q with Phosphorylation of p38 Mitogen-Activated Protein Kinase and Apoptotic Features

Sandra Bordin and Douglas Whitfield
J Immunol 2003 170: 667-671. [Abstract] [Full Text] [PDF]  

Cutting Edge: Homeostatic Proliferation of Peripheral T Lymphocytes Is Regulated by Clonal Competition

Amy E. Troy and Hao Shen
J Immunol 2003 170: 672-676. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Inhibition of Metalloproteinase Cleavage Enhances the Cytotoxicity of Fas Ligand

Pauline G. Knox, Anne E. Milner, Nicky K. Green, Aristides G. Eliopoulos, and Lawrence S. Young
J Immunol 2003 170: 677-685. [Abstract] [Full Text] [PDF]  

Intrinsic Differences in the Proliferation of Naive and Memory Human B Cells as a Mechanism for Enhanced Secondary Immune Responses

Stuart G. Tangye, Danielle T. Avery, Elissa K. Deenick, and Philip D. Hodgkin
J Immunol 2003 170: 686-694. [Abstract] [Full Text] [PDF]  

Hypoxia Regulates Expression and Activity of Kv1.3 Channels in T Lymphocytes: A Possible Role in T Cell Proliferation

Laura Conforti, Milan Petrovic, Dina Mohammad, Susan Lee, Qing Ma, Sharon Barone, and Alexandra H. Filipovich
J Immunol 2003 170: 695-702. [Abstract] [Full Text] [PDF]  

Impaired Lymphopoiesis and Altered B Cell Subpopulations in Mice Overexpressing Lnk Adaptor Protein

Satoshi Takaki, Yoshinari Tezuka, Karsten Sauer, Chiyomi Kubo, Sang-Mo Kwon, Erin Armstead, Kazuki Nakao, Motoya Katsuki, Roger M. Perlmutter, and Kiyoshi Takatsu
J Immunol 2003 170: 703-710. [Abstract] [Full Text] [PDF]  

Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses

Frann Bennett, Deborah Luxenberg, Vincent Ling, I-Ming Wang, Kim Marquette, David Lowe, Nighat Khan, Geertruida Veldman, Kenneth A. Jacobs, Viia E. Valge-Archer, Mary Collins, and Beatriz M. Carreno
J Immunol 2003 170: 711-718. [Abstract] [Full Text] [PDF]  

Decreased E12 and/or E47 Transcription Factor Activity in the Bone Marrow As Well As in the Spleen of Aged Mice

Daniela Frasca, Diep Nguyen, Richard L. Riley, and Bonnie B. Blomberg
J Immunol 2003 170: 719-726. [Abstract] [Full Text] [PDF]  

CD154 Plays a Central Role in Regulating Dendritic Cell Activation During Infections That Induce Th1 or Th2 Responses

Amy D. Straw, Andrew S. MacDonald, Eric Y. Denkers, and Edward J. Pearce
J Immunol 2003 170: 727-734. [Abstract] [Full Text] [PDF]  

Either IL-2 or IL-12 Is Sufficient to Direct Th1 Differentiation by Nonobese Diabetic T Cells

Weisong Zhou, Feng Zhang, and Thomas M. Aune
J Immunol 2003 170: 735-740. [Abstract] [Full Text] [PDF]  

CD4⁺ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo

Farida Bouzahzah, Sungsoo Jung, and Joseph Craft
J Immunol 2003 170: 741-748. [Abstract] [Full Text] [PDF]  

Down-Modulation of Responses to Type I IFN Upon T Cell Activation

Elisabetta Dondi, Lars Rogge, Georges Lutfalla, Gilles Uzé, and Sandra Pellegrini
J Immunol 2003 170: 749-756. [Abstract] [Full Text] [PDF]  

Mechanisms of Enhanced Macrophage-Mediated Prostaglandin E₂ Production and Its Suppressive Role in Th1 Activation in Th2-Dominant BALB/c Mice

Etsushi Kuroda and Uki Yamashita
J Immunol 2003 170: 757-764. [Abstract] [Full Text] [PDF]  

Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the V8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10

Todd A. Braciak, Brian Pedersen, Judy Chin, Clay Hsiao, E. Sally Ward, Igor Maricic, Alex Jahng, Frank L. Graham, Jack Gauldie, Eli E. Sercarz, and Vipin Kumar
J Immunol 2003 170: 765-774. [Abstract] [Full Text] [PDF]  

Long Term Maintenance of IgE-Mediated Memory in Mast Cells in the Absence of Detectable Serum IgE

Shuichi Kubo, Toshinori Nakayama, Kunie Matsuoka, Hiromichi Yonekawa, and Hajime Karasuyama
J Immunol 2003 170: 775-780. [Abstract] [Full Text] [PDF]  

Differential Requirements for Expression of CD80/86 and CD40 on B Cells for T-Dependent Antibody Responses In Vivo

Joanne M. Lumsden, Joy A. Williams, and Richard J. Hodes
J Immunol 2003 170: 781-787. [Abstract] [Full Text] [PDF]  

Complement Component 3 Is Required for Optimal Expansion of CD8 T Cells During a Systemic Viral Infection

M. Suresh, Hector Molina, Maria S. Salvato, Dimitrios Mastellos, John D. Lambris, and Matyas Sandor
J Immunol 2003 170: 788-794. [Abstract] [Full Text] [PDF]  

Endotoxin/Lipopolysaccharide Activates NF-B and Enhances Tumor Cell Adhesion and Invasion Through a ₁ Integrin-Dependent Mechanism

Jiang Huai Wang, Brian J. Manning, Qiong Di Wu, Siobhan Blankson, D. Bouchier-Hayes, and H. Paul Redmond
J Immunol 2003 170: 795-804. [Abstract] [Full Text] [PDF]  

The Intracellular Granzyme B Inhibitor, Proteinase Inhibitor 9, Is Up-Regulated During Accessory Cell Maturation and Effector Cell Degranulation, and Its Overexpression Enhances CTL Potency

Claire E. Hirst, Marguerite S. Buzza, Catherina H. Bird, Hilary S. Warren, Paul U. Cameron, Manling Zhang, Philip G. Ashton-Rickardt, and Phillip I. Bird
J Immunol 2003 170: 805-815. [Abstract] [Full Text] [PDF]  

Microbial Colonization Drives Lymphocyte Accumulation and Differentiation in the Follicle-Associated Epithelium of Peyer’s Patches

Takeshi Yamanaka, Lars Helgeland, Inger Nina Farstad, Hisanori Fukushima, Tore Midtvedt, and Per Brandtzaeg
J Immunol 2003 170: 816-822. [Abstract] [Full Text] [PDF]  

Indoleamine 2,3-Dioxygenase Is Regulated by IFN- in the Mouse Placenta During Listeria monocytogenes Infection

Ari M. Mackler, Ellen M. Barber, Osamu Takikawa, and Jeffrey W. Pollard
J Immunol 2003 170: 823-830. [Abstract] [Full Text] [PDF]  

Nonmyelin-Specific T Cells Accelerate Development of Central Nervous System APC and Increase Susceptibility to Experimental Autoimmune Encephalomyelitis

Richard E. Jones, Thomas Kay, Thomas Keller, and Dennis Bourdette
J Immunol 2003 170: 831-837. [Abstract] [Full Text] [PDF]  

IL-6 and Matrix Metalloproteinase-1 Are Regulated by the Cyclin-Dependent Kinase Inhibitor p21 in Synovial Fibroblasts

Harris Perlman, Kathleen Bradley, Hongtao Liu, Shawn Cole, Eli Shamiyeh, Roy C. Smith, Kenneth Walsh, Stefano Fiore, Alisa E. Koch, Gary S. Firestein, G. Kenneth Haines, III, and Richard M. Pope
J Immunol 2003 170: 838-845. [Abstract] [Full Text] [PDF]  

A Critical Role for Syk Protein Tyrosine Kinase in Fc Receptor-Mediated Antigen Presentation and Induction of Dendritic Cell Maturation

Christine Sedlik, Daniel Orbach, Philippe Veron, Edina Schweighoffer, Francesco Colucci, Romina Gamberale, Andrea Ioan-Facsinay, Sjef Verbeek, Paola Ricciardi-Castagnoli, Christian Bonnerot, Victor L. J. Tybulewicz, James Di Santo, and Sebastian Amigorena
J Immunol 2003 170: 846-852. [Abstract] [Full Text] [PDF]  

IFN- Production Is Specifically Regulated by IL-10 in Mice Made Tolerant with Anti-CD40 Ligand Antibody and Intact Active Bone

Dengping Yin, Nadav Dujovny, Lianli Ma, Anncy Varghese, JiKun Shen, D. Keith Bishop, and Anita S. Chong
J Immunol 2003 170: 853-860. [Abstract] [Full Text] [PDF]  

A Thyroid Tumor-Specific Antigen Formed by the Fusion of Two Self Proteins

Daniel J. Powell, Jr., Laurence C. Eisenlohr, and Jay L. Rothstein
J Immunol 2003 170: 861-869. [Abstract] [Full Text] [PDF]  

Detection of Autoreactive Myelin Proteolipid Protein 139–151-Specific T Cells by Using MHC II (IA^s) Tetramers

Jayagopala Reddy, Estelle Bettelli, Lindsay Nicholson, Hanspeter Waldner, Mei-Huei Jang, Kai W. Wucherpfennig, and Vijay K. Kuchroo
J Immunol 2003 170: 870-877. [Abstract] [Full Text] [PDF]  

Suppressor of Cytokine Signaling-1 Has IFN--Independent Actions in T Cell Homeostasis

Ann L. Cornish, Gayle M. Davey, Donald Metcalf, Jared F. Purton, Jason E. Corbin, Christopher J. Greenhalgh, Rima Darwiche, Li Wu, Nicos A. Nicola, Dale I. Godfrey, William R. Heath, Douglas J. Hilton, Warren S. Alexander, and Robyn Starr
J Immunol 2003 170: 878-886. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

IL-4 Induces Apoptosis in A549 Lung Adenocarcinoma Cells: Evidence for the Pivotal Role of 15-Hydroxyeicosatetraenoic Acid Binding to Activated Peroxisome Proliferator-Activated Receptor Transcription Factor

Pattabhiraman Shankaranarayanan and Santosh Nigam
J Immunol 2003 170: 887-894. [Abstract] [Full Text] [PDF]  

T Cell Chemokine Receptor Expression in Aging

Ruran Mo, Jun Chen, Yin Han, Cecelia Bueno-Cannizares, David E. Misek, Pascal A. Lescure, Samir Hanash, and Raymond L. Yung
J Immunol 2003 170: 895-904. [Abstract] [Full Text] [PDF]  

Lipid Raft-Independent B Cell Receptor-Mediated Antigen Internalization and Intracellular Trafficking

Michelle A. Putnam, Amy E. Moquin, Megan Merrihew, Christopher Outcalt, Emily Sorge, Adriana Caballero, Timothy A. Gondré-Lewis, and James R. Drake
J Immunol 2003 170: 905-912. [Abstract] [Full Text] [PDF]  

Lipid Raft Distribution of CD4 Depends on its Palmitoylation and Association with Lck, and Evidence for CD4-Induced Lipid Raft Aggregation as an Additional Mechanism to Enhance CD3 Signaling

Roben Fragoso, Dejian Ren, Xiaoping Zhang, Michael Wei-Chih Su, Steven J. Burakoff, and Yong-Jiu Jin
J Immunol 2003 170: 913-921. [Abstract] [Full Text] [PDF]  

The GTP-Binding Domain of Class II Transactivator Regulates Its Nuclear Export

Aparna Raval, Jocelyn D. Weissman, T. Kevin Howcroft, and Dinah S. Singer
J Immunol 2003 170: 922-930. [Abstract] [Full Text] [PDF]  

Up-Regulation of Early Growth Response Gene-1 Via the CXCR3 Receptor Induces Reactive Oxygen Species and Inhibits Na⁺/K⁺-ATPase Activity in an Immortalized Human Proximal Tubule Cell Line

Martin J. Bek, Hans C. Reinhardt, Karl-Georg Fischer, Jochen R. Hirsch, Charlotte Hupfer, Eileen Dayal, and Hermann Pavenstädt
J Immunol 2003 170: 931-940. [Abstract] [Full Text] [PDF]  

Impaired Transporter Associated with Antigen Processing (TAP) Function Attributable to a Single Amino Acid Alteration in the Peptide TAP Subunit TAP1

Ulrike Ritz, Ingo Drexler, Dirk Sutter, Rupert Abele, Christoph Huber, and Barbara Seliger
J Immunol 2003 170: 941-946. [Abstract] [Full Text] [PDF]  

Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid Decarboxylase 65-Specific TCRs

Yasushi Uemura, Satoru Senju, Katsumi Maenaka, Leo Kei Iwai, Shinji Fujii, Hiroki Tabata, Hirotake Tsukamoto, Shinya Hirata, Yu-Zhen Chen, and Yasuharu Nishimura
J Immunol 2003 170: 947-960. [Abstract] [Full Text] [PDF]  

A Single Polymorphic Residue Within the Peptide-Binding Cleft of MHC Class I Molecules Determines Spectrum of Tapasin Dependence

Boyoun Park, Sungwook Lee, Euijae Kim, and Kwangseog Ahn
J Immunol 2003 170: 961-968. [Abstract] [Full Text] [PDF]  

The GDP Exchange Factor AND-34 Is Expressed in B Cells, Associates With HEF1, and Activates Cdc42

Dongpo Cai, Kyriakos N. Felekkis, Richard I. Near, Geraldine M. O’Neill, Jean Maguire van Seventer, Erica A. Golemis, and Adam Lerner
J Immunol 2003 170: 969-978. [Abstract] [Full Text] [PDF]  

A Complex Containing Polypyrimidine Tract-Binding Protein Is Involved in Regulating the Stability of CD40 Ligand (CD154) mRNA

Penelope A. Kosinski, Jennifer Laughlin, Karnail Singh, and Lori R. Covey
J Immunol 2003 170: 979-988. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Targeting with Bovine CD154 Enhances Humoral Immune Responses Induced by a DNA Vaccine in Sheep

Sharmila Manoj, Philip J. Griebel, Lorne A. Babiuk, and Sylvia van Drunen Littel-van den Hurk
J Immunol 2003 170: 989-996. [Abstract] [Full Text] [PDF]  

Identification of IFN Regulatory Factor-1 Binding Site in IL-12 p40 Gene Promoter

Saho Maruyama, Kohsuke Sumita, Hua Shen, Makoto Kanoh, Xin Xu, Mitsuharu Sato, Masahito Matsumoto, Hiroto Shinomiya, and Yoshihiro Asano
J Immunol 2003 170: 997-1001. [Abstract] [Full Text] [PDF]  

IL-10 Modulates Host Responses and Lung Damage Induced by Pneumocystis carinii Infection

Mahboob H. Qureshi, Allen G. Harmsen, and Beth A. Garvy
J Immunol 2003 170: 1002-1009. [Abstract] [Full Text] [PDF]  

Autocrine Type I IFN and Contact with Endothelium Promote the Presentation of Influenza A Virus by Monocyte-Derived APC

Chunfeng Qu, Thomas M. Moran, and Gwendalyn J. Randolph
J Immunol 2003 170: 1010-1018. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Novel Quantitative Trait Loci Controlling Development of Experimental Autoimmune Encephalomyelitis and Proportion of Lymphocyte Subpopulations

Jenny Karlsson, Xiangshan Zhao, Irina Lonskaya, Malin Neptin, Rikard Holmdahl, and Åsa Andersson
J Immunol 2003 170: 1019-1026. [Abstract] [Full Text] [PDF]  

Acceleration of Human Neutrophil Apoptosis by TRAIL

Stephen A. Renshaw, Jasvir S. Parmar, Vanessa Singleton, Sarah J. Rowe, David H. Dockrell, Steven K. Dower, Colin D. Bingle, Edwin R. Chilvers, and Moira K. B. Whyte
J Immunol 2003 170: 1027-1033. [Abstract] [Full Text] [PDF]  

Role of Vesicle-Associated Membrane Protein-2, Through Q-Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor/R-Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Interaction, in the Exocytosis of Specific and Tertiary Granules of Human Neutrophils

Faustino Mollinedo, Belén Martín-Martín, Jero Calafat, Svetlana M. Nabokina, and Pedro A. Lazo
J Immunol 2003 170: 1034-1042. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Expression by Nonsteroidal Anti-inflammatory Drugs in Human Airway Smooth Muscle Cells: Role of Peroxisome Proliferator-Activated Receptors

Linhua Pang, Mei Nie, Lisa Corbett, and Alan J. Knox
J Immunol 2003 170: 1043-1051. [Abstract] [Full Text] [PDF]  

CpG DNA Induces Self and Cross-Hyporesponsiveness of RAW264.7 Cells in Response to CpG DNA and Lipopolysaccharide: Alterations in IL-1 Receptor-Associated Kinase Expression

Seon-Ju Yeo, Jae-Geun Yoon, Soon-Cheol Hong, and Ae-Kyung Yi
J Immunol 2003 170: 1052-1061. [Abstract] [Full Text] [PDF]  

New Loci Regulating Rat Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis

Kristina Becanovic, Erik Wallstrom, Barbara Kornek, Anna Glaser, Karl W. Broman, Ingrid Dahlman, Peter Olofsson, Rikard Holmdahl, Holger Luthman, Hans Lassmann, and Tomas Olsson
J Immunol 2003 170: 1062-1069. [Abstract] [Full Text] [PDF]  

Regulation of Cyclooxygenase-2 Expression by Macrophages in Response to Double-Stranded RNA and Viral Infection

Sarah A. Steer, Jason M. Moran, Leonard B. Maggi, Jr., R. Mark L. Buller, Harris Perlman, and John A. Corbett
J Immunol 2003 170: 1070-1076. [Abstract] [Full Text] [PDF]  

Enhanced Th2 Cell-Mediated Allergic Inflammation in Tyk2-Deficient Mice

Yohei Seto, Hiroshi Nakajima, Akira Suto, Kazuya Shimoda, Yasushi Saito, Keiichi I. Nakayama, and Itsuo Iwamoto
J Immunol 2003 170: 1077-1083. [Abstract] [Full Text] [PDF]  

Chemoattraction of Human T Cells by IL-18

Mousa Komai-Koma, J. Alastair Gracie, Xiao-qing Wei, Damo Xu, Neil Thomson, Iain B. McInnes, and Foo Y. Liew
J Immunol 2003 170: 1084-1090. [Abstract] [Full Text] [PDF]  

Selective IB Kinase Expression in Airway Epithelium Generates Neutrophilic Lung Inflammation

Ruxana T. Sadikot, Wei Han, M. Brett Everhart, Ornella Zoia, R. Stokes Peebles, E. Duco Jansen, Fiona E. Yull, John W. Christman, and Timothy S. Blackwell
J Immunol 2003 170: 1091-1098. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

CD8 T Cells Are Not Essential to the Pathogenesis of Arthritis or Colitis in HLA-B27 Transgenic Rats

Ekkehard May, Martha L. Dorris, Nimman Satumtira, Imran Iqbal, Muhammad I. Rehman, Ellis Lightfoot, and Joel D. Taurog
J Immunol 2003 170: 1099-1105. [Abstract] [Full Text] [PDF]  

Diverse Repertoire of HIV-1 p24-Specific, IFN--Producing CD4⁺ T Cell Clones Following Immune Reconstitution on Highly Active Antiretroviral Therapy

Eli Boritz, Brent E. Palmer, Brian Livingston, Alessandro Sette, and Cara C. Wilson
J Immunol 2003 170: 1106-1116. [Abstract] [Full Text] [PDF]  

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