CUTTING EDGE:

Cutting Edge: Cellular Fas-Associated Death Domain-Like IL-1-Converting Enzyme-Inhibitory Protein Protects Germinal Center B Cells from Apoptosis During Germinal Center Reactions

Marco van Eijk, Jan Paul Medema, and Cornelis de Groot
J Immunol 2001 166: 6473-6476. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Unique Subpopulations of CD56⁺ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire

James J. Campbell, Shixin Qin, Derya Unutmaz, Dulce Soler, Kristine E. Murphy, Martin R. Hodge, Lijun Wu, and Eugene C. Butcher
J Immunol 2001 166: 6477-6482. [Abstract] [Full Text] [PDF]  

Low-Level Monocyte Chemoattractant Protein-1 Stimulation of Monocytes Leads to Tumor Formation in Nontumorigenic Melanoma Cells

Mark Nesbit, Helmut Schaider, Thomas H. Miller, and Meenhard Herlyn
J Immunol 2001 166: 6483-6490. [Abstract] [Full Text] [PDF]  

Mechanism of Melphalan-Induced B7-1 Gene Expression in P815 Tumor Cells

Manjula Donepudi, Pradip Raychaudhuri, Jeffrey A. Bluestone, and Margalit B. Mokyr
J Immunol 2001 166: 6491-6499. [Abstract] [Full Text] [PDF]  

The Role of Adoptively Transferred CD8 T Cells and Host Cells in the Control of the Growth of the EG7 Thymoma: Factors That Determine the Relative Effectiveness and Homing Properties of Tc1 and Tc2 Effectors

Brian K. Helmich and Richard W. Dutton
J Immunol 2001 166: 6500-6508. [Abstract] [Full Text] [PDF]  

Overexpression of Bcl-2 Differentially Restores Development of Thymus-Derived CD4^-8⁺ T Cells and Intestinal Intraepithelial T Cells in IFN-Regulatory Factor-1-Deficient Mice

Toshiaki Ohteki, Chikako Maki, and Shigeo Koyasu
J Immunol 2001 166: 6509-6513. [Abstract] [Full Text] [PDF]  

Identification of MHC Class II-Associated Peptides That Promote the Presentation of Toxic Shock Syndrome Toxin-1 to T Cells

Robert J. Hogan, Josine VanBeek, Dana R. Broussard, Sherri L. Surman, and David L. Woodland
J Immunol 2001 166: 6514-6522. [Abstract] [Full Text] [PDF]  

LFA-1-Mediated Costimulation of CD8⁺ T Cell Proliferation Requires Phosphatidylinositol 3-Kinase Activity

Hsiao-Tzu Ni, Matthew J. Deeths, and Matthew F. Mescher
J Immunol 2001 166: 6523-6529. [Abstract] [Full Text] [PDF]  

A Transcriptional Block in the IL-2 Promoter at the -150 AP-1 Site in Effector CD8⁺ T Cells

Rosalynde J. Finch, Patrick E. Fields, and Philip D. Greenberg
J Immunol 2001 166: 6530-6536. [Abstract] [Full Text] [PDF]  

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 on Murine Dendritic Cells Is a Potent Regulator of T Cell Stimulation

Robert Kammerer, Detlef Stober, Bernhard B. Singer, Björn Öbrink, and Jörg Reimann
J Immunol 2001 166: 6537-6544. [Abstract] [Full Text] [PDF]  

Molecular Identification of IgE-Dependent Histamine-Releasing Factor as a B Cell Growth Factor

Hyung Sik Kang, Min Ju Lee, Hyunkeun Song, Seung Hyun Han, Yong Man Kim, Joo Young Im, and Inpyo Choi
J Immunol 2001 166: 6545-6554. [Abstract] [Full Text] [PDF]  

Three Different Vaccines Based on the 140-Amino Acid MUC1 Peptide with Seven Tandemly Repeated Tumor-Specific Epitopes Elicit Distinct Immune Effector Mechanisms in Wild-Type Versus MUC1-Transgenic Mice with Different Potential for Tumor Rejection

M. Melina Soares, Vinay Mehta, and Olivera J. Finn
J Immunol 2001 166: 6555-6563. [Abstract] [Full Text] [PDF]  

Phosphatidylinositol 3'-Kinase Blocks CD95 Aggregation and Caspase-8 Cleavage at the Death-Inducing Signaling Complex by Modulating Lateral Diffusion of CD95

Arun S. Varadhachary, Michael Edidin, Allison M. Hanlon, Marcus E. Peter, Peter H. Krammer, and Padmini Salgame
J Immunol 2001 166: 6564-6569. [Abstract] [Full Text] [PDF]  

Inhibition of p38 Kinase Reveals a TNF--Mediated, Caspase-Dependent, Apoptotic Death Pathway in a Human Myelomonocyte Cell Line

Jishy Varghese, Souvik Chattopadhaya, and Apurva Sarin
J Immunol 2001 166: 6570-6577. [Abstract] [Full Text] [PDF]  

Mechanisms of the Antimetastatic Effect in the Liver and of the Hepatocyte Injury Induced by -Galactosylceramide in Mice

Ryusuke Nakagawa, Ikuko Nagafune, Yoshiko Tazunoki, Hiromi Ehara, Hitomi Tomura, Rieko Iijima, Kazuhiro Motoki, Masaru Kamishohara, and Shuhji Seki
J Immunol 2001 166: 6578-6584. [Abstract] [Full Text] [PDF]  

MHC Class I-Ly49 Interactions Shape the Ly49 Repertoire on Murine NK Cells

Linda Fahlén, Urban Lendahl, and Charles L. Sentman
J Immunol 2001 166: 6585-6592. [Abstract] [Full Text] [PDF]  

The Fetal Liver Counterpart of Adult Common Lymphoid Progenitors Gives Rise to All Lymphoid Lineages, CD45⁺CD4⁺CD3^- Cells, As Well As Macrophages

Reina E. Mebius, Toshihiro Miyamoto, Julie Christensen, Jos Domen, Tom Cupedo, Irving L. Weissman, and Koichi Akashi
J Immunol 2001 166: 6593-6601. [Abstract] [Full Text] [PDF]  

A Low Affinity TCR Ligand Restores Positive Selection of CD8⁺ T Cells In Vivo

Heather E. Stefanski, Dita Mayerova, Stephen C. Jameson, and Kristin A. Hogquist
J Immunol 2001 166: 6602-6607. [Abstract] [Full Text] [PDF]  

Cyclophosphamide Induces the Development of Early Myeloid Cells Suppressing Tumor Cell Growth by a Nitric Oxide-Dependent Mechanism

Blondineth Peláez, José A. Campillo, José A. López-Asenjo, and José L. Subiza
J Immunol 2001 166: 6608-6615. [Abstract] [Full Text] [PDF]  

Early TCR Expression Promotes Maturation of T Cells Expressing FcRI Containing TCR/CD3 Complexes

Karin Petersson and Fredrik Ivars
J Immunol 2001 166: 6616-6624. [Abstract] [Full Text] [PDF]  

Clustering of Peptide-Loaded MHC Class I Molecules for Endoplasmic Reticulum Export Imaged by Fluorescence Resonance Energy Transfer

Tsvetelina Pentcheva and Michael Edidin
J Immunol 2001 166: 6625-6632. [Abstract] [Full Text] [PDF]  

A Novel Pathway Regulating Lipopolysaccharide-Induced Shock by ST2/T1 Via Inhibition of Toll-Like Receptor 4 Expression

Matthew J. Sweet, Bernard P. Leung, Daiwu Kang, Morten Sogaard, Kerstin Schulz, Vladimir Trajkovic, Carol C. Campbell, Damo Xu, and Foo Y. Liew
J Immunol 2001 166: 6633-6639. [Abstract] [Full Text] [PDF]  

Rigidity of Circulating Lymphocytes Is Primarily Conferred by Vimentin Intermediate Filaments

Martin J. Brown, John A. Hallam, Emma Colucci-Guyon, and Stephen Shaw
J Immunol 2001 166: 6640-6646. [Abstract] [Full Text] [PDF]  

Induction of Telomerase Activity During Development of Human Mast Cells from Peripheral Blood CD34⁺ Cells: Comparisons with Tumor Mast-Cell Lines

Cristina Chaves-Dias, Thomas R. Hundley, Alasdair M. Gilfillan, Arnold S. Kirshenbaum, Jose Renan Cunha-Melo, Dean D. Metcalfe, and Michael A. Beaven
J Immunol 2001 166: 6647-6656. [Abstract] [Full Text] [PDF]  

Prolonged Antigen Persistence Within Nonterminal Late Endocytic Compartments of Antigen-Specific B Lymphocytes

Timothy A. Gondré-Lewis, Amy E. Moquin, and James R. Drake
J Immunol 2001 166: 6657-6664. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Tetramer-Guided Epitope Mapping: Rapid Identification and Characterization of Immunodominant CD4⁺ T Cell Epitopes from Complex Antigens

Erik J. Novak, Andrew W. Liu, John A. Gebe, Ben A. Falk, Gerald T. Nepom, David M. Koelle, and William W. Kwok
J Immunol 2001 166: 6665-6670. [Abstract] [Full Text] [PDF]  

An Alternative Form of IL-18 in Human Blood Plasma: Complex Formation with IgM Defined by Monoclonal Antibodies

Kyoko Shida, Ikuo Shiratori, Misak Matsumoto, Yasuo Fukumori, Akio Matsuhisa, Satomi Kikkawa, Shoutaro Tsuji, Haruki Okamura, Kumao Toyoshima, and Tsukasa Seya
J Immunol 2001 166: 6671-6679. [Abstract] [Full Text] [PDF]  

Peptide Binding to Active Class II MHC Protein on the Cell Surface

Judith F. Vacchino and Harden M. McConnell
J Immunol 2001 166: 6680-6685. [Abstract] [Full Text] [PDF]  

Association of ERp57 with Mouse MHC Class I Molecules Is Tapasin Dependent and Mimics That of Calreticulin and not Calnexin

Michael R. Harris, Lonnie Lybarger, Yik Y. L. Yu, Nancy B. Myers, and Ted H. Hansen
J Immunol 2001 166: 6686-6692. [Abstract] [Full Text] [PDF]  

Flexibility in MHC and TCR Recognition: Degenerate Specificity at the T Cell Level in the Recognition of Promiscuous Th Epitopes Exhibiting No Primary Sequence Homology

Sunil K. Joshi, Padma R. Suresh, and Virander S. Chauhan
J Immunol 2001 166: 6693-6703. [Abstract] [Full Text] [PDF]  

Dissociation of Pax-5 from KI and KII Sites During -Chain Gene Rearrangement Correlates with Its Association with the Underphosphorylated Form of Retinoblastoma

Hiromu Sato, Dan Wang, and Akira Kudo
J Immunol 2001 166: 6704-6710. [Abstract] [Full Text] [PDF]  

Immunological and Biochemical Characterization of Streptococcal Pyrogenic Exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes

Thomas Proft, Vickery L. Arcus, Vanessa Handley, Edward N. Baker, and John D. Fraser
J Immunol 2001 166: 6711-6719. [Abstract] [Full Text] [PDF]  

Naturally Processed HLA Class II Peptides Reveal Highly Conserved Immunogenic Flanking Region Sequence Preferences That Reflect Antigen Processing Rather Than Peptide-MHC Interactions

Andrew J. Godkin, Kathrine J. Smith, Anthony Willis, Maria V. Tejada-Simon, Jingwu Zhang, Tim Elliott, and Adrian V. S. Hill
J Immunol 2001 166: 6720-6727. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

TNF- Controls Intracellular Mycobacterial Growth by Both Inducible Nitric Oxide Synthase-Dependent and Inducible Nitric Oxide Synthase-Independent Pathways

Linda-Gail Bekker, Sherry Freeman, Peter J. Murray, Bernard Ryffel, and Gilla Kaplan
J Immunol 2001 166: 6728-6734. [Abstract] [Full Text] [PDF]  

Serum Amyloid P Component Binds to Fc Receptors and Opsonizes Particles for Phagocytosis

Dwaipayan Bharadwaj, Carolyn Mold, Eric Markham, and Terry W. Du Clos
J Immunol 2001 166: 6735-6741. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-Activated Receptor -Retinoid X Receptor Agonists Increase CD36-Dependent Phagocytosis of Plasmodium falciparum-Parasitized Erythrocytes and Decrease Malaria-Induced TNF- Secretion by Monocytes/Macrophages

Lena Serghides and Kevin C. Kain
J Immunol 2001 166: 6742-6748. [Abstract] [Full Text] [PDF]  

T Cells Enhance Production of IL-18 by Monocytes in Response to an Intracellular Pathogen

Ramakrishna Vankayalapati, Benjamin Wizel, David L. Lakey, Yueru Zhang, Keith A. Coffee, David E. Griffith, and Peter F. Barnes
J Immunol 2001 166: 6749-6753. [Abstract] [Full Text] [PDF]  

P2X₇ Nucleotide Receptor Mediation of Membrane Pore Formation and Superoxide Generation in Human Promyelocytes and Neutrophils

Byung-Chang Suh, Jong-So Kim, Uk Namgung, Hyunjung Ha, and Kyong-Tai Kim
J Immunol 2001 166: 6754-6763. [Abstract] [Full Text] [PDF]  

A Novel Interaction Between Type IV Pili of Neisseria gonorrhoeae and the Human Complement Regulator C4b-Binding Protein

Anna M. Blom, Anne Rytkönen, Paola Vasquez, Gunnar Lindahl, Björn Dahlbäck, and Ann-Beth Jonsson
J Immunol 2001 166: 6764-6770. [Abstract] [Full Text] [PDF]  

A Retroviral-Derived Immunosuppressive Peptide Activates Mitogen-Activated Protein Kinases

Akio Takahashi, Noorbibi K. Day, Voravich Luangwedchakarn, Robert A. Good, and Soichi Haraguchi
J Immunol 2001 166: 6771-6775. [Abstract] [Full Text] [PDF]  

BALB/c Mice Bearing a Transgenic IL-12 Receptor 2 Gene Exhibit a Nonhealing Phenotype to Leishmania major Infection Despite Intact IL-12 Signaling

Ryuta Nishikomori, Sanjay Gurunathan, Kanako Nishikomori, and Warren Strober
J Immunol 2001 166: 6776-6783. [Abstract] [Full Text] [PDF]  

Innate Immunity to Viruses: Control of Vaccinia Virus Infection by T Cells

Liisa K. Selin, Paul A. Santolucito, Amelia K. Pinto, Eva Szomolanyi-Tsuda, and Raymond M. Welsh
J Immunol 2001 166: 6784-6794. [Abstract] [Full Text] [PDF]  

Distinct Roles for PECAM-1, ICAM-1, and VCAM-1 in Recruitment of Neutrophils and Eosinophils to the Cornea in Ocular Onchocerciasis (River Blindness)

Jussuf T. Kaifi, Eugenia Diaconu, and Eric Pearlman
J Immunol 2001 166: 6795-6801. [Abstract] [Full Text] [PDF]  

Differential Involvement of Dendritic Cell Subsets During Acute Salmonella Infection

Alun C. Kirby, Ulf Yrlid, Mattias Svensson, and Mary Jo Wick
J Immunol 2001 166: 6802-6811. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

CD40 Activates NF-B and c-Jun N-Terminal Kinase and Enhances Chemokine Secretion on Activated Human Hepatic Stellate Cells

Robert F. Schwabe, Bernd Schnabl, Young O. Kweon, and David A. Brenner
J Immunol 2001 166: 6812-6819. [Abstract] [Full Text] [PDF]  

Accelerated Nephrotoxic Nephritis Is Exacerbated in C1q-Deficient Mice

Michael G. Robson, H. Terence Cook, Marina Botto, Philip R. Taylor, Nathalie Busso, Roberto Salvi, Charles D. Pusey, Mark J. Walport, and Kevin A. Davies
J Immunol 2001 166: 6820-6828. [Abstract] [Full Text] [PDF]  

PU.1 and Multiple IFN Regulatory Factor Proteins Synergize to Mediate Transcriptional Activation of the Human IL-1 Gene

Sylvia Marecki, Carrie J. Riendeau, Michael D. Liang, and Matthew J. Fenton
J Immunol 2001 166: 6829-6838. [Abstract] [Full Text] [PDF]  

IB Kinase Is Critical for TNF--Induced VCAM1 Gene Expression in Renal Tubular Epithelial Cells

Zheng Tu, Vicki Rubin Kelley, Tucker Collins, and Frank S. Lee
J Immunol 2001 166: 6839-6846. [Abstract] [Full Text] [PDF]  

Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases

Valerie A. Fadok, Donna L. Bratton, Lindsay Guthrie, and Peter M. Henson
J Immunol 2001 166: 6847-6854. [Abstract] [Full Text] [PDF]  

Bacterial DNA and Lipopolysaccharide Induce Synergistic Production of TNF- Through a Post-Transcriptional Mechanism

Jian Jun Gao, Qiao Xue, Christopher J. Papasian, and David C. Morrison
J Immunol 2001 166: 6855-6860. [Abstract] [Full Text] [PDF]  

Reversing Lipopolysaccharide Toxicity by Ligating the Macrophage Fc Receptors

Jeffrey S. Gerber and David M. Mosser
J Immunol 2001 166: 6861-6868. [Abstract] [Full Text] [PDF]  

Activation of Human Macrophages by Amyloid- Is Attenuated by Astrocytes

Hessel A. Smits, Astrid J. van Beelen, N. Machiel de Vos, Annemarie Rijsmus, Tjomme van der Bruggen, Jan Verhoef, Freek L. van Muiswinkel, and Hans S. L. M. Nottet
J Immunol 2001 166: 6869-6876. [Abstract] [Full Text] [PDF]  

The p38 Mitogen-Activated Protein Kinase Mediates Cytoskeletal Remodeling in Pulmonary Microvascular Endothelial Cells Upon Intracellular Adhesion Molecule-1 Ligation

Qin Wang and Claire M. Doerschuk
J Immunol 2001 166: 6877-6884. [Abstract] [Full Text] [PDF]  

G₁₆ Couples Chemoattractant Receptors to NF-B Activation

Ming Yang, Hairong Sang, Arshad Rahman, Dianqing Wu, Asrar B. Malik, and Richard D. Ye
J Immunol 2001 166: 6885-6892. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Blockade of CD40 Ligand Suppresses Chronic Experimental Myasthenia Gravis by Down-Regulation of Th1 Differentiation and Up-Regulation of CTLA-4

Sin-Hyeog Im, Dora Barchan, Prasanta Kumar Maiti, Sara Fuchs, and Miriam C. Souroujon
J Immunol 2001 166: 6893-6898. [Abstract] [Full Text] [PDF]  

Chemokine Receptor CCR4 on CD4⁺ T Cells in Juvenile Rheumatoid Arthritis Synovial Fluid Defines a Subset of Cells with Increased IL-4:IFN- mRNA Ratios

Susan D. Thompson, Lorie K. Luyrink, T. Brent Graham, Monica Tsoras, Mary Ryan, Murray H. Passo, and David N. Glass
J Immunol 2001 166: 6899-6906. [Abstract] [Full Text] [PDF]  

Thiopalmitoylation of Myelin Proteolipid Protein Epitopes Enhances Immunogenicity and Encephalitogenicity

Judith M. Greer, Bérangère Denis, Raymond A. Sobel, and Elisabeth Trifilieff
J Immunol 2001 166: 6907-6913. [Abstract] [Full Text] [PDF]  

Western and Chinese Antirheumatic Drug-Induced T Cell Apoptotic DNA Damage Uses Different Caspase Cascades and Is Independent of Fas/Fas Ligand Interaction

Jenn-Haung Lai, Ling-Jun Ho, Kuo-Cheng Lu, Deh-Ming Chang, Men-Fang Shaio, and Shou-Hwa Han
J Immunol 2001 166: 6914-6924. [Abstract] [Full Text] [PDF]  

A Glutamic Acid Decarboxylase 65-Specific Th2 Cell Clone Immunoregulates Autoimmune Diabetes in Nonobese Diabetic Mice

Roland Tisch, Bo Wang, Mark A. Atkinson, David V. Serreze, and Randall Friedline
J Immunol 2001 166: 6925-6936. [Abstract] [Full Text] [PDF]  

Vascular Adhesion Protein 1 Mediates Binding of Immunotherapeutic Effector Cells to Tumor Endothelium

Heikki Irjala, Marko Salmi, Kalle Alanen, Reidar Grénman, and Sirpa Jalkanen
J Immunol 2001 166: 6937-6943. [Abstract] [Full Text] [PDF]  

IFN--Inducible Protein-10 Is Essential for the Generation of a Protective Tumor-Specific CD8 T Cell Response Induced by Single-Chain IL-12 Gene Therapy

Ursula Pertl, Andrew D. Luster, Nissi M. Varki, Dirk Homann, Gerhard Gaedicke, Ralph A. Reisfeld, and Holger N. Lode
J Immunol 2001 166: 6944-6951. [Abstract] [Full Text] [PDF]  

Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4⁺ T Lymphocytes in Humans

Richard S. Hotchkiss, Kevin W. Tinsley, Paul E. Swanson, Robert E. Schmieg, Jr., Jia Ji Hui, Katherine C. Chang, Dale F. Osborne, Bradley D. Freeman, J. Perren Cobb, Timothy G. Buchman, and Irene E. Karl
J Immunol 2001 166: 6952-6963. [Abstract] [Full Text] [PDF]  

Fas Ligand Overexpression on Allograft Endothelium Inhibits Inflammatory Cell Infiltration and Transplant-Associated Intimal Hyperplasia

Masataka Sata, Zhengyu Luo, and Kenneth Walsh
J Immunol 2001 166: 6964-6971. [Abstract] [Full Text] [PDF]  

CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice

Vivianne Malmström, Deborah Shipton, Baljit Singh, Aymen Al-Shamkhani, Michael J. Puklavec, A. Neil Barclay, and Fiona Powrie
J Immunol 2001 166: 6972-6981. [Abstract] [Full Text] [PDF]  

The Allergen-Induced Airway Hyperresponsiveness in a Human-Mouse Chimera Model of Asthma Is T Cell and IL-4 and IL-5 Dependent

Kurt G. Tournoy, Johan C. Kips, and Romain A. Pauwels
J Immunol 2001 166: 6982-6991. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction for vol. 166, p. 4237

J Immunol 2001 166: 6992. [Full Text] [PDF]  

Correction for vol. 166, p. 232

J Immunol 2001 166: 6992. [Full Text] [PDF]  

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