CUTTING EDGE:

Cutting Edge: Polycomb Gene Expression Patterns Reflect Distinct B Cell Differentiation Stages in Human Germinal Centers

Frank M. Raaphorst, Folkert J. van Kemenade, Elly Fieret, Karien M. Hamer, David P. E. Satijn, Arie P. Otte, and Chris J. L. M. Meijer
J Immunol 2000 164: 1-4. [Abstract] [Full Text] [PDF]  

Cutting Edge: Tyrosine-Independent Transmission of Inhibitory Signals by CTLA-4

Tomas Cinek, Ali Sadra, and John B. Imboden
J Immunol 2000 164: 5-8. [Abstract] [Full Text] [PDF]  

Cutting Edge: Signal-Regulatory Protein ß1 Is a DAP12-Associated Activating Receptor Expressed in Myeloid Cells

Jes Dietrich, Marina Cella, Martina Seiffert, Hans-Jörg Bühring, and Marco Colonna
J Immunol 2000 164: 9-12. [Abstract] [Full Text] [PDF]  

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

Amir Kol, Andrew H. Lichtman, Robert W. Finberg, Peter Libby, and Evelyn A. Kurt-Jones
J Immunol 2000 164: 13-17. [Abstract] [Full Text] [PDF]  

Cutting Edge: Lack of Peripheral B Cells and Severe Agammaglobulinemia in Mice Simultaneously Lacking Bruton’s Tyrosine Kinase and the B Cell-Specific Transcriptional Coactivator OBF-1

Daniel B. Schubart, Antonius Rolink, Karin Schubart, and Patrick Matthias
J Immunol 2000 164: 18-22. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

IFN-ß Differentially Regulates CD40-Induced Cytokine Secretion by Human Dendritic Cells

Bradford L. McRae, Beth A. Beilfuss, and Gijs A. van Seventer
J Immunol 2000 164: 23-28. [Abstract] [Full Text] [PDF]  

Protein Kinase C Is Required for the Induction of Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages

Annabel F. Valledor, Jordi Xaus, Mònica Comalada, Concepció Soler, and Antonio Celada
J Immunol 2000 164: 29-37. [Abstract] [Full Text] [PDF]  

Development of Lupus in BXSB Mice Is Independent of IL-4

Dwight H. Kono, Dimitrios Balomenos, Miyo S. Park, and Argyrios N. Theofilopoulos
J Immunol 2000 164: 38-42. [Abstract] [Full Text] [PDF]  

Human Intestinal Mast Cells Are Capable of Producing Different Cytokine Profiles: Role of IgE Receptor Cross-Linking and IL-4

Axel Lorentz, Silke Schwengberg, Gernot Sellge, Michael P. Manns, and Stephan C. Bischoff
J Immunol 2000 164: 43-48. [Abstract] [Full Text] [PDF]  

The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation

Miren L. Baroja, Deborah Luxenberg, Thu Chau, Vincent Ling, Craig A. Strathdee, Beatriz M. Carreno, and Joaquín Madrenas
J Immunol 2000 164: 49-55. [Abstract] [Full Text] [PDF]  

Distinct Role of Follicular Dendritic Cells and T Cells in the Proliferation, Differentiation, and Apoptosis of a Centroblast Cell Line, L3055

Jongseon Choe, Li Li, Xin Zhang, Christopher D. Gregory, and Yong Sung Choi
J Immunol 2000 164: 56-63. [Abstract] [Full Text] [PDF]  

Synergistic Effects of IL-4 and IL-18 on IL-12-Dependent IFN- Production by Dendritic Cells

Taro Fukao, Satoshi Matsuda, and Shigeo Koyasu
J Immunol 2000 164: 64-71. [Abstract] [Full Text] [PDF]  

Inhibition of IL-4 Responses After T Cell Priming in the Context of LFA-1 Costimulation Is Not Reversed by Restimulation in the Presence of CD28 Costimulation

Scott A. Jenks and Jim Miller
J Immunol 2000 164: 72-78. [Abstract] [Full Text] [PDF]  

Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection

Joanne M. Lumsden, Joanna M. Roberts, Nicola L. Harris, Robert J. Peach, and Franca Ronchese
J Immunol 2000 164: 79-85. [Abstract] [Full Text] [PDF]  

Bovine and Human Insulin Activate CD8⁺-Autoreactive CTL Expressing Both Type 1 and Type 2 Cytokines in C57BL/6 Mice

Hakling Ma, Yong Ke, Qingqin Li, and Judith A. Kapp
J Immunol 2000 164: 86-92. [Abstract] [Full Text] [PDF]  

An Early Pseudorabies Virus Protein Down-Regulates Porcine MHC Class I Expression by Inhibition of Transporter Associated with Antigen Processing (TAP)

Aruna P. N. Ambagala, Susanne Hinkley, and Subramaniam Srikumaran
J Immunol 2000 164: 93-99. [Abstract] [Full Text] [PDF]  

Role of Costimulation in the Induction of the IL-12/IL-12 Receptor Pathway and the Development of Autoimmunity

John T. Chang, Benjamin M. Segal, and Ethan M. Shevach
J Immunol 2000 164: 100-106. [Abstract] [Full Text] [PDF]  

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

Joseph R. Maxwell, Andrew Weinberg, Rodney A. Prell, and Anthony T. Vella
J Immunol 2000 164: 107-112. [Abstract] [Full Text] [PDF]  

Developmental Expression of Insulin Receptor Substrate-2 During Dimethylsulfoxide-Induced Differentiation of Human HL-60 Cells

Daniel H. Schacher, Roger W. VanHoy, Qiang Liu, Sean Arkins, Robert Dantzer, Gregory G. Freund, and Keith W. Kelley
J Immunol 2000 164: 113-120. [Abstract] [Full Text] [PDF]  

Deriving Quantitative Constraints on T Cell Selection from Data on the Mature T Cell Repertoire

Vincent Detours, Ramit Mehr, and Alan S. Perelson
J Immunol 2000 164: 121-128. [Abstract] [Full Text] [PDF]  

Modification of the Amino Terminus of a Class II Epitope Confers Resistance to Degradation by CD13 on Dendritic Cells and Enhances Presentation to T Cells

Xin Dong, Bing An, Lisa Salvucci Kierstead, Walter J. Storkus, Andrew A. Amoscato, and Russell D. Salter
J Immunol 2000 164: 129-135. [Abstract] [Full Text] [PDF]  

A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade

Ann M. Girvin, Mauro C. Dal Canto, Lesley Rhee, Benoît Salomon, Arlene Sharpe, Jeffrey A. Bluestone, and Stephen D. Miller
J Immunol 2000 164: 136-143. [Abstract] [Full Text] [PDF]  

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

Leonard J. Appleman, Alla Berezovskaya, Isabelle Grass, and Vassiliki A. Boussiotis
J Immunol 2000 164: 144-151. [Abstract] [Full Text] [PDF]  

Effects of T3R1 and T3R2 Gene Deletion on T and B Lymphocyte Development

Christophe Arpin, Maria Pihlgren, Alexandre Fraichard, Denise Aubert, Jacques Samarut, Olivier Chassande, and Jacqueline Marvel
J Immunol 2000 164: 152-160. [Abstract] [Full Text] [PDF]  

Dendritic Cells Genetically Engineered to Express Fas Ligand Induce Donor-Specific Hyporesponsiveness and Prolong Allograft Survival

Wei-Ping Min, Reginald Gorczynski, Xu-Yan Huang, Michelle Kushida, Peter Kim, Masayuki Obataki, Ji Lei, Rakesh M. Suri, and Mark S. Cattral
J Immunol 2000 164: 161-167. [Abstract] [Full Text] [PDF]  

Bacterial Proteins Can Be Processed by Macrophages in a Transporter Associated with Antigen Processing-Independent, Cysteine Protease-Dependent Manner for Presentation by MHC Class I Molecules

Daniel J. Campbell, Thomas Serwold, and Nilabh Shastri
J Immunol 2000 164: 168-175. [Abstract] [Full Text] [PDF]  

Glycine Inhibits Growth of T Lymphocytes by an IL-2-Independent Mechanism

Robert F. Stachlewitz, Xiangli Li, Scott Smith, Hartwig Bunzendahl, Lee M. Graves, and Ronald G. Thurman
J Immunol 2000 164: 176-182. [Abstract] [Full Text] [PDF]  

Suppressor Effector Function of CD4⁺CD25⁺ Immunoregulatory T Cells Is Antigen Nonspecific

Angela M. Thornton and Ethan M. Shevach
J Immunol 2000 164: 183-190. [Abstract] [Full Text] [PDF]  

Characterization of CD8⁺ T Lymphocytes That Persist After Peripheral Tolerance to a Self Antigen Expressed in the Pancreas

C. Thomas Nugent, David J. Morgan, Judith A. Biggs, Alice Ko, Ingrid M. Pilip, Eric G. Pamer, and Linda A. Sherman
J Immunol 2000 164: 191-200. [Abstract] [Full Text] [PDF]  

Surface Expression of the IFN-R2 Chain Is Regulated by Intracellular Trafficking in Human T Lymphocytes

Laura Rigamonti, Silvia Ariotti, Giuliana Losana, Roberto Gradini, Matteo A. Russo, Emmanuelle Jouanguy, Jean-Laurent Casanova, Guido Forni, and Francesco Novelli
J Immunol 2000 164: 201-207. [Abstract] [Full Text] [PDF]  

Activated and Memory CD8⁺ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers

Mark K. Slifka and J. Lindsay Whitton
J Immunol 2000 164: 208-216. [Abstract] [Full Text] [PDF]  

Gene Transfer of IFN- into Established Brain Tumors Represses Growth by Antiangiogenesis

Hassan M. Fathallah-Shaykh, Li-Juan Zhao, Abdallah I. Kafrouni, George M. Smith, and James Forman
J Immunol 2000 164: 217-222. [Abstract] [Full Text] [PDF]  

Vaccination with Heat-Killed Listeria as Adjuvant Reverses Established Allergen-Induced Airway Hyperreactivity and Inflammation: Role of CD8⁺ T Cells and IL-18

Gesine Hansen, V. Peter Yeung, Gerald Berry, Dale T. Umetsu, and Rosemarie H. DeKruyff
J Immunol 2000 164: 223-230. [Abstract] [Full Text] [PDF]  

IFN--Dependent Delay of In Vivo Tumor Progression by Fas Overexpression on Murine Renal Cancer Cells

Jong-Keuk Lee, Thomas J. Sayers, Alan D. Brooks, Timothy C. Back, Howard A. Young, Kristin L. Komschlies, Jon M. Wigginton, and Robert H. Wiltrout
J Immunol 2000 164: 231-239. [Abstract] [Full Text] [PDF]  

Characterization of Peripheral Regulatory CD4⁺ T Cells That Prevent Diabetes Onset in Nonobese Diabetic Mice

Françoise Lepault and Marie Claude Gagnerault
J Immunol 2000 164: 240-247. [Abstract] [Full Text] [PDF]  

Th2-Dependent B Cell Responses in the Absence of CD40-CD40 Ligand Interactions

Narendra Chirmule, John Tazelaar, and James M. Wilson
J Immunol 2000 164: 248-255. [Abstract] [Full Text] [PDF]  

A Role for Pref-1 and HES-1 in Thymocyte Development

Midori Kaneta, Masatake Osawa, Mitsujiro Osawa, Kazuhiro Sudo, Hiromitsu Nakauchi, Andrew G. Farr, and Yousuke Takahama2
J Immunol 2000 164: 256-264. [Abstract] [Full Text] [PDF]  

Functional Responses and Costimulator Dependence of Memory CD4⁺ T Cells

Cheryl A. London, Michael P. Lodge, and Abul K. Abbas
J Immunol 2000 164: 265-272. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Importance of the Membrane-Proximal Extracellular Domains for Activation of the Signal Transducer Glycoprotein 130

Ingo Kurth, Ursula Horsten, Stefan Pflanz, Andreas Timmermann, Andrea Küster, Heike Dahmen, Ingrid Tacken, Peter C. Heinrich, and Gerhard Müller-Newen
J Immunol 2000 164: 273-282. [Abstract] [Full Text] [PDF]  

Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques

John L. Dzuris, John Sidney, Ettore Appella, Robert W. Chesnut, David I. Watkins, and Alessandro Sette
J Immunol 2000 164: 283-291. [Abstract] [Full Text] [PDF]  

Distinct Functions of Tapasin Revealed by Polymorphism in MHC Class I Peptide Loading

Chen Au Peh, Nihay Laham, Scott R. Burrows, Yong Zhu, and James McCluskey
J Immunol 2000 164: 292-299. [Abstract] [Full Text] [PDF]  

The Role of Sp Family Members, Basic Krupple-Like Factor, and E Box Factors in the Basal and IFN- Regulated Expression of the Human Complement C4 Promoter

Daniela Ulgiati, Lily S. Subrata, and Lawrence J. Abraham
J Immunol 2000 164: 300-307. [Abstract] [Full Text] [PDF]  

Anergic T Lymphocytes Selectively Express an Integrin Regulatory Protein of the Cytohesin Family

Ulf Korthäuer, Wolfgang Nagel, Elizabeth M. Davis, Michelle M. Le Beau, Raman S. Menon, Elizabeth O. Mitchell, Christine A. Kozak, Waldemar Kolanus, and Jeffrey A. Bluestone
J Immunol 2000 164: 308-318. [Abstract] [Full Text] [PDF]  

HLA-F Is a Predominantly Empty, Intracellular, TAP-Associated MHC Class Ib Protein with a Restricted Expression Pattern

Shane D. Wainwright, P. Andrew Biro, and Christopher H. Holmes
J Immunol 2000 164: 319-328. [Abstract] [Full Text] [PDF]  

Limited Diversity of Peptides Related to an Alloreactive T Cell Epitope in the HLA-B27-Bound Peptide Repertoire Results from Restrictions at Multiple Steps Along the Processing-Loading Pathway

Alberto Paradela, Iñaki Alvarez, Marina García-Peydró, Laura Sesma, Manuel Ramos, Jesús Vázquez, and José A. López de Castro
J Immunol 2000 164: 329-337. [Abstract] [Full Text] [PDF]  

Point Mutation of a Tyrosine in the Linker Region of Syk Results in a Gain of Function

Kiyonao Sada, Juan Zhang, and Reuben P. Siraganian
J Immunol 2000 164: 338-344. [Abstract] [Full Text] [PDF]  

Rescue of Defective T Cell Development and Function in Atm^-/- Mice by a Functional TCRß Transgene

Connie Chao, Eva Marie Yang, and Yang Xu
J Immunol 2000 164: 345-349. [Abstract] [Full Text] [PDF]  

Convergence of Fc Receptor IIA and Fc Receptor IIIB Signaling Pathways in Human Neutrophils

Frank Y. S. Chuang, Massimo Sassaroli, and Jay C. Unkeless
J Immunol 2000 164: 350-360. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis

Marina Stolina, Sherven Sharma, Ying Lin, Mariam Dohadwala, Brian Gardner, Jie Luo, Li Zhu, Mitchell Kronenberg, Patrice W. Miller, Joseph Portanova, Jason C. Lee, and Steven M. Dubinett
J Immunol 2000 164: 361-370. [Abstract] [Full Text] [PDF]  

IL-4 and IL-10 Antagonize IL-12-Mediated Protection Against Acute Vaccinia Virus Infection with a Limited Role of IFN- and Nitric Oxide Synthetase 2

Maries van den Broek, Martin F. Bachmann, Gabriele Köhler, Marijke Barner, Rüdiger Escher, Rolf Zinkernagel, and Manfred Kopf
J Immunol 2000 164: 371-378. [Abstract] [Full Text] [PDF]  

ATP-Induced Killing of Virulent Mycobacterium tuberculosis Within Human Macrophages Requires Phospholipase D

David J. Kusner and Juan Adams
J Immunol 2000 164: 379-388. [Abstract] [Full Text] [PDF]  

Macrophage Control of Mycobacterial Growth Induced by Picolinic Acid Is Dependent on Host Cell Apoptosis

Teresa F. Pais and Rui Appelberg
J Immunol 2000 164: 389-397. [Abstract] [Full Text] [PDF]  

Differential Contribution of Fas- and Perforin-Mediated Mechanisms to the Cell-Mediated Cytotoxic Activity of Naive and In Vivo-Primed Intestinal Intraepithelial Lymphocytes

Nadia Corazza, Stefan Müller, Thomas Brunner, David Kägi, and Christoph Mueller
J Immunol 2000 164: 398-403. [Abstract] [Full Text] [PDF]  

fMet-Leu-Phe Stimulates Proinflammatory Cytokine Gene Expression in Human Peripheral Blood Monocytes: The Role of Phosphatidylinositol 3-Kinase

Zhixing K. Pan, Ling-Yu Chen, Charles G. Cochrane, and Bruce L. Zuraw
J Immunol 2000 164: 404-411. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Role of B7-CD28/CTLA-4 Costimulation and NF-B in Allergen-Induced T Cell Chemotaxis by IL-16 and RANTES

Rabia Hidi, Vanessa Riches, Musa Al-Ali, William W. Cruikshank, David M. Center, Stephen T. Holgate, and Ratko Djukanovic
J Immunol 2000 164: 412-418. [Abstract] [Full Text] [PDF]  

Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis

Amy E. Juedes, Peter Hjelmström, Cheryl M. Bergman, Annie L. Neild, and Nancy H. Ruddle
J Immunol 2000 164: 419-426. [Abstract] [Full Text] [PDF]  

Monocyte Migration Through the Alveolar Epithelial Barrier: Adhesion Molecule Mechanisms and Impact of Chemokines

Simone Rosseau, Jochen Selhorst, Kristina Wiechmann, Katja Leissner, Ulrich Maus, Konstantin Mayer, Friedrich Grimminger, Werner Seeger, and Jürgen Lohmeyer
J Immunol 2000 164: 427-435. [Abstract] [Full Text] [PDF]  

Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes

Amrey A. Link, Tomoshige Kino, James A. Worth, Jennifer L. McGuire, Marianna L. Crane, George P. Chrousos, Ronald L. Wilder, and Ilia J. Elenkov
J Immunol 2000 164: 436-442. [Abstract] [Full Text] [PDF]  

TNF- Receptor Signaling and IL-10 Gene Therapy Regulate the Innate and Humoral Immune Responses to Recombinant Adenovirus in the Lung

Rebecca M. Minter, John E. Rectenwald, Kunitaro Fukuzuka, Cynthia L. Tannahill, Drake La Face, Van Tsai, Iqbal Ahmed, Elizabeth Hutchins, Richard Moyer, Edward M. Copeland, III, and Lyle L. Moldawer
J Immunol 2000 164: 443-451. [Abstract] [Full Text] [PDF]  

Antibodies Against the First Ig-Like Domain of Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Inhibit PECAM-1-Dependent Homophilic Adhesion Block In Vivo Neutrophil Recruitment

Marian T. Nakada, Kunjlata Amin, Melpo Christofidou-Solomidou, Christopher D. O’Brien, Jing Sun, Indira Gurubhagavatula, George A. Heavner, Alexander H. Taylor, Cathy Paddock, Qi-Hong Sun, James L. Zehnder, Peter J. Newman, Steven M. Albelda, and Horace M. DeLisser
J Immunol 2000 164: 452-462. [Abstract] [Full Text] [PDF]  

The Arthus Reaction in Rodents: Species-Specific Requirement of Complement

Alexander J. Szalai, Stanley B. Digerness, Alok Agrawal, John F. Kearney, R. Pat Bucy, Shri Niwas, John M. Kilpatrick, Y. Sudhakara Babu, and John E. Volanakis
J Immunol 2000 164: 463-468. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Fas-Deficient lpr Mice Are More Susceptible to Graft-Versus-Host Disease

Marcel R. M. van den Brink, Ellen Moore, Kirsten J. Horndasch, James M. Crawford, Jean Hoffman, George F. Murphy, and Steven J. Burakoff
J Immunol 2000 164: 469-480. [Abstract] [Full Text] [PDF]  

Immunogenicity and Arthritogenicity of Recombinant CB10 in B10.RIII Mice

Bo Tang, David D. Brand, Tom M. Chiang, John M. Stuart, Andrew H. Kang, and Linda K. Myers
J Immunol 2000 164: 481-487. [Abstract] [Full Text] [PDF]  

Up-Regulation of IL-12 in Monocytes: A Fundamental Defect in Common Variable Immunodeficiency

Rosario Cambronero, W. A. Carrock Sewell, Margaret E. North, A. David B. Webster, and John Farrant
J Immunol 2000 164: 488-494. [Abstract] [Full Text] [PDF]  

Expansion of Tumor-T Cell Pairs from Fine Needle Aspirates of Melanoma Metastases

Monica C. Panelli, Adam Riker, Udai Kammula, Ena Wang, Kang-Hun Lee, Steven A. Rosenberg, and Francesco M. Marincola
J Immunol 2000 164: 495-504. [Abstract] [Full Text] [PDF]  

Protection of Murine Lupus by the Ea^d Transgene Is MHC Haplotype-Dependent

Nabila Ibnou-Zekri, Masahiro Iwamoto, M. Eric Gershwin, and Shozo Izui
J Immunol 2000 164: 505-511. [Abstract] [Full Text] [PDF]  

Treatment of Allograft Recipients with Donor-Specific Transfusion and Anti-CD154 Antibody Leads to Deletion of Alloreactive CD8⁺ T Cells and Prolonged Graft Survival in a CTLA4-Dependent Manner

Neal N. Iwakoshi, John P. Mordes, Thomas G. Markees, Nancy E. Phillips, Aldo A. Rossini, and Dale L. Greiner
J Immunol 2000 164: 512-521. [Abstract] [Full Text] [PDF]  

Immune Modulation in Pemphigus Vulgaris: Role of CD28 and IL-10

Paola Toto, Claudio Feliciani, Paolo Amerio, Hirotake Suzuki, Binghe Wang, Gulnar M. Shivji, David Woodley, and Daniel N. Sauder
J Immunol 2000 164: 522-529. [Abstract] [Full Text] [PDF]  

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