CUTTING EDGE:

Cutting Edge: Induction of Antigen-Specific Hyporesponsiveness by Transplantation of Hemopoietic Cells Containing an MHC Class I Transgene Regulated by a Lymphocyte-Specific Promoter

Susan A. Hansal, Diane I. Morris, Joan M. G. Sechler, Paul E. Love, and Amy S. Rosenberg
J Immunol 1998 161: 1063-1068. [Abstract] [Full Text] [PDF]  

Cutting Edge: Curative Treatment of an Experimentally Induced Colitis by a CD44 Variant V7-Specific Antibody

Bianca Wittig, Christoph Schwärzler, Nicole Föhr, Ursula Günthert, and Margot Zöller
J Immunol 1998 161: 1069-1073. [Abstract] [Full Text] [PDF]  

Cutting Edge: A Conditionally Active Form of STAT6 Can Mimic Certain Effects of IL-4

Yumiko Kamogawa, Hyun Jun Lee, James A. Johnston, Martin McMahon, Anne O’Garra, and Naoko Arai
J Immunol 1998 161: 1074-1077. [Abstract] [Full Text] [PDF]  

Cutting Edge: A Newly Identified Response Element in the CD95 Ligand Promoter Contributes to Optimal Inducibility in Activated T Lymphocytes

Lyse A. Norian, Kevin M. Latinis, and Gary A. Koretzky
J Immunol 1998 161: 1078-1082. [Abstract] [Full Text] [PDF]  

Cutting Edge: Differential Regulation of Chemokine Receptors During Dendritic Cell Maturation: A Model for Their Trafficking Properties

Silvano Sozzani, Paola Allavena, Giovanna D’Amico, Walter Luini, Giancarlo Bianchi, Motoji Kataura, Toshio Imai, Osamu Yoshie, Raffaella Bonecchi, and Alberto Mantovani
J Immunol 1998 161: 1083-1086. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

T Cell Vaccination in Experimental Autoimmune Encephalomyelitis: A Mathematical Model

José A. M. Borghans, Rob J. De Boer, Eli Sercarz, and Vipin Kumar
J Immunol 1998 161: 1087-1093. [Abstract] [Full Text] [PDF]  

Novel Diversity in Th1, Th2 Type Differentiation of Hemagglutinin-Specific T Cell Clones Elicited by Natural Influenza Virus Infection in Three Major Haplotypes (H-2^b,d,k)

Christine M. Graham, Claire A. Smith, and D. Brian Thomas
J Immunol 1998 161: 1094-1103. [Abstract] [Full Text] [PDF]  

Kinetics of Expression of Costimulatory Molecules and Their Ligands in Murine Relapsing Experimental Autoimmune Encephalomyelitis In Vivo

Shohreh Issazadeh, Vaidrius Navikas, Meike Schaub, Mohamed Sayegh, and Samia Khoury
J Immunol 1998 161: 1104-1112. [Abstract] [Full Text] [PDF]  

Serine 16 of Stathmin as a Cytosolic Target for Ca²⁺/Calmodulin-Dependent Kinase II After CD2 Triggering of Human T Lymphocytes

Sabine le Gouvello, Valérie Manceau, and André Sobel
J Immunol 1998 161: 1113-1122. [Abstract] [Full Text] [PDF]  

A Pivotal Role of Cyclin D3 and Cyclin-Dependent Kinase Inhibitor p27 in the Regulation of IL-2-, IL-4-, or IL-10-Mediated Human B Cell Proliferation

Eric F. Wagner, Marija Hleb, Nazeeh Hanna, and Surendra Sharma
J Immunol 1998 161: 1123-1131. [Abstract] [Full Text] [PDF]  

Surrogate Light Chain Production During B Cell Differentiation: Differential Intracellular Versus Cell Surface Expression

Yui-Hsi Wang, Jun Nomura, Ona Marie Faye-Petersen, and Max D. Cooper
J Immunol 1998 161: 1132-1139. [Abstract] [Full Text] [PDF]  

IL-12 Promotes the Adhesion of NK Cells to Endothelial Selectins Under Flow Conditions

Tadayuki Yago, Mamoru Tsukuda, Hirofumi Fukushima, Hideyuki Yamaoka, Kazumi Kurata-Miura, Tatsunari Nishi, and Mutsuhiko Minami
J Immunol 1998 161: 1140-1145. [Abstract] [Full Text] [PDF]  

Dendritic Cell Heterogeneity In Vivo: Two Functionally Different Dendritic Cell Populations in Rat Intestinal Lymph Can Be Distinguished by CD4 Expression

LiMing Liu, ManHua Zhang, Chris Jenkins, and G. Gordon MacPherson
J Immunol 1998 161: 1146-1155. [Abstract] [Full Text] [PDF]  

Tolerance Induction by Anti-CD2 Plus Anti-CD3 Monoclonal Antibodies: Evidence for an IL-4 Requirement

Jeffrey D. Punch, Takeshi Tono, Lihui Qin, D. Keith Bishop, and Jonathan S. Bromberg
J Immunol 1998 161: 1156-1162. [Abstract] [Full Text] [PDF]  

B Lymphocytes Are Crucial Antigen-Presenting Cells in the Pathogenic Autoimmune Response to GAD65 Antigen in Nonobese Diabetic Mice

Marika Falcone, Jae Lee, Gail Patstone, Brian Yeung, and Nora Sarvetnick
J Immunol 1998 161: 1163-1168. [Abstract] [Full Text] [PDF]  

Characterization of a Novel Bax-Associated Protein Expressed in Hemopoietic Tissues and Regulated During Thymocyte Apoptosis

Huiling He, Pamela A. Hershberger, and Susan A. McCarthy
J Immunol 1998 161: 1169-1175. [Abstract] [Full Text] [PDF]  

Down-Modulation of a Novel Bax-Associated Protein During Apoptosis in Normal Mature B Lymphocytes

Huiling He, Pamela A. Hershberger, and Susan A. McCarthy
J Immunol 1998 161: 1176-1182. [Abstract] [Full Text] [PDF]  

TNF Receptor-Associated Factor-3 Signaling Mediates Activation of p38 and Jun N-Terminal Kinase, Cytokine Secretion, and Ig Production Following Ligation of CD40 on Human B Cells

Amrie C. Grammer, Jennifer L. Swantek, Richard D. McFarland, Yasushi Miura, Thomas Geppert, and Peter E. Lipsky
J Immunol 1998 161: 1183-1193. [Abstract] [Full Text] [PDF]  

CD4 Regulation of TCR Signaling and T Cell Differentiation Following Stimulation with Peptides of Different Affinities for the TCR

David Leitenberg, Yvan Boutin, Stephanie Constant, and Kim Bottomly
J Immunol 1998 161: 1194-1203. [Abstract] [Full Text] [PDF]  

Induction of Acute Inflammation In Vivo by Staphylococcal Superantigens. II. Critical Role for Chemokines, ICAM-1, and TNF-

Philippe A. Tessier, Paul H. Naccache, Kerrilyn R. Diener, Ronald P. Gladue, Kuldeep S. Neote, Ian Clark-Lewis, and Shaun R. McColl
J Immunol 1998 161: 1204-1211. [Abstract] [Full Text] [PDF]  

Characterization of High Density Lipoprotein-Bound and Soluble RT6 Released Following Administration of Anti-RT6.1 Monoclonal Antibody

Elena Lesma, Joel Moss, H. Bryan Brewer, Rita Bortell, Dale Greiner, John Mordes, and Aldo A. Rossini
J Immunol 1998 161: 1212-1219. [Abstract] [Full Text] [PDF]  

Human Melanoma-Reactive CD4⁺ and CD8⁺ CTL Clones Resist Fas Ligand-Induced Apoptosis and Use Fas/Fas Ligand-Independent Mechanisms for Tumor Killing

Licia Rivoltini, Marina Radrizzani, Paola Accornero, Paola Squarcina, Claudia Chiodoni, Arabella Mazzocchi, Chiara Castelli, Paolo Tarsini, Vincenzo Viggiano, Filiberto Belli, Mario P. Colombo, and Giorgio Parmiani
J Immunol 1998 161: 1220-1230. [Abstract] [Full Text] [PDF]  

L-Selectin-Specific Autoantibodies in Murine Lupus: Possible Involvement in Abnormal Homing and Polarization of CD4⁺ T Cell Subsets

Susumu Hattori, Hiroyuki Nishimura, Hiromichi Tsurui, Masayuki Kato, Naoki Endo, Masaaki Abe, Shin Akakura, Kenichi Mitsui, Sho Ishikawa, Sachiko Hirose, and Toshikazu Shirai
J Immunol 1998 161: 1231-1238. [Abstract] [Full Text] [PDF]  

IL-4-Producing NK1.1⁺ T Cells Are Resistant to Glucocorticoid-Induced Apoptosis: Implications for the Th1/Th2 Balance

Koji Tamada, Mamoru Harada, Koichiro Abe, Tieli Li, and Kikuo Nomoto
J Immunol 1998 161: 1239-1247. [Abstract] [Full Text] [PDF]  

Monocyte-Dependent Death of Freshly Isolated T Lymphocytes: Induction by Phorbolester and Mitogens and Differential Effects of Catalase

Daniela Wesch, Sibylle Marx, and Dieter Kabelitz
J Immunol 1998 161: 1248-1256. [Abstract] [Full Text] [PDF]  

Staphylococcal Enterotoxin A Induces Survival of V_H3-Expressing Human B Cells by Binding to the V_H Region with Low Affinity

Rana Domiati-Saad and Peter E. Lipsky
J Immunol 1998 161: 1257-1266. [Abstract] [Full Text] [PDF]  

A Subset of CD4⁺ T Cells Expressing Early Activation Antigen CD69 in Murine Lupus: Possible Abnormal Regulatory Role for Cytokine Imbalance

Sho Ishikawa, Shin Akakura, Masaaki Abe, Kazuo Terashima, Karina Chijiiwa, Hiroyuki Nishimura, Sachiko Hirose, and Toshikazu Shirai
J Immunol 1998 161: 1267-1273. [Abstract] [Full Text] [PDF]  

Autoreactivity of Human VH Domains from cDNA Libraries: Analysis with a Bacterial Expression System

Jean-Michel Lecerf, Yan Chen, Pascale Richalet-Sécordel, Xiaowei Wang, and B. David Stollar
J Immunol 1998 161: 1274-1283. [Abstract] [Full Text] [PDF]  

Characterization and Differentiation of an Early Murine Yolk Sac-Derived IL-7-Independent Pre-Pro-B Cell Line

Li-Sheng Lu and Robert Auerbach
J Immunol 1998 161: 1284-1291. [Abstract] [Full Text] [PDF]  

Indirect T Cell Allorecognition and Alloantibody-Mediated Rejection of MHC Class I-Disparate Heart Grafts

Gavin J. Pettigrew, Emma Lovegrove, J. Andrew Bradley, John Maclean, and Eleanor M. Bolton
J Immunol 1998 161: 1292-1298. [Abstract] [Full Text] [PDF]  

Zinc Bound to the Killer Cell-Inhibitory Receptor Modulates the Negative Signal in Human NK Cells

Sumati Rajagopalan and Eric O. Long
J Immunol 1998 161: 1299-1305. [Abstract] [Full Text] [PDF]  

Human and Nonhuman Primate Lymphocytes Engrafted into SCID Mice Reside in Unique Mesenteric Lymphoid Structures

Hollie Hale Donze, James E. Cummins, Jr., Rebecca S. Schwiebert, Patricia N. Fultz, Susan Jackson, and Jiri Mestecky
J Immunol 1998 161: 1306-1312. [Abstract] [Full Text] [PDF]  

Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response

Michelle Wykes, Ana Pombo, Chris Jenkins, and G. Gordon MacPherson
J Immunol 1998 161: 1313-1319. [Abstract] [Full Text] [PDF]  

Pig MHC Mediates Positive Selection of Mouse CD4⁺ T Cells with a Mouse MHC-Restricted TCR in Pig Thymus Grafts

Yong Zhao, Kirsten Swenson, Justin J. Sergio, and Megan Sykes
J Immunol 1998 161: 1320-1326. [Abstract] [Full Text] [PDF]  

Origin and Characteristics of Ultraviolet-B Radiation-Induced Suppressor T Lymphocytes

Vijay K. Shreedhar, Michael W. Pride, Yan Sun, Margaret L. Kripke, and Faith M. Strickland
J Immunol 1998 161: 1327-1335. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Efficient Recombination of a Switch Substrate Retrovector in CD40-Activated B Lymphocytes: Implications for the Control of C_H Gene Switch Recombination

Jack Ballantyne, Diane L. Henry, Jurgen R. Muller, Francine Briere, Clifford M. Snapper, Marilyn Kehry, and Kenneth B. Marcu
J Immunol 1998 161: 1336-1347. [Abstract] [Full Text] [PDF]  

Mouse MD-1, a Molecule That Is Physically Associated with RP105 and Positively Regulates Its Expression

Kensuke Miyake, Rintaro Shimazu, Jun Kondo, Tamotsu Niki, Sachiko Akashi, Hirotaka Ogata, Yoshio Yamashita, Yoshihiro Miura, and Masao Kimoto
J Immunol 1998 161: 1348-1353. [Abstract] [Full Text] [PDF]  

Generation of Switch Hybrid DNA Between Ig Heavy Chain-µ and Downstream Switch Regions in B Lymphocytes

Jürgen R. Müller, Thomas Giese, Diane L. Henry, J. Frederic Mushinski, and Kenneth B. Marcu
J Immunol 1998 161: 1354-1362. [Abstract] [Full Text] [PDF]  

The Leukocyte Function-Associated Antigen-1 (LFA-1)-Binding Site on ICAM-3 Comprises Residues on Both Faces of the First Immunoglobulin Domain

Elaine D. Bell, Andrew P. May, and David L. Simmons
J Immunol 1998 161: 1363-1370. [Abstract] [Full Text] [PDF]  

Cytokine-Like Factor-1, a Novel Soluble Protein, Shares Homology with Members of the Cytokine Type I Receptor Family

Greg C. A. Elson, Pierre Graber, Christophe Losberger, Suzanne Herren, Denise Gretener, Laurent N. Menoud, Timothy N. C. Wells, Marie H. Kosco-Vilbois, and Jean-François Gauchat
J Immunol 1998 161: 1371-1379. [Abstract] [Full Text] [PDF]  

Th2-Specific Protein/DNA Interactions at the Proximal Nuclear Factor-AT Site Contribute to the Functional Activity of the Human IL-4 Promoter

Min Li-Weber, Padmini Salgame, Chenggang Hu, Ilia V. Davydov, Oskar Laur, Sibylle Klevenz, and Peter H. Krammer
J Immunol 1998 161: 1380-1389. [Abstract] [Full Text] [PDF]  

The Mitogen-Activated Protein Kinase Pathway Inhibits Ceramide-Induced Terminal Differentiation of a Human Monoblastic Leukemia Cell Line, U937

Scott J. Ragg, Shuji Kaga, Karen A. Berg, and Atsuo Ochi
J Immunol 1998 161: 1390-1398. [Abstract] [Full Text] [PDF]  

A Developmental Stage-Specific Promoter Directs Germline Transcription of DßJß Gene Segments in Precursor T Lymphocytes

Michael L. Sikes, Rey J. Gomez, Jing Song, and Eugene M. Oltz
J Immunol 1998 161: 1399-1405. [Abstract] [Full Text] [PDF]  

Sequence-Based Typing Provides a New Look at HLA-C Diversity

Seán Turner, Mary E. Ellexson, Heather D. Hickman, David A. Sidebottom, Marcelo Fernández-Viña, Dennis L. Confer, and William H. Hildebrand
J Immunol 1998 161: 1406-1413. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Homogeneous Escherichia coli Chaperonin 60 Induces IL-1ß and IL-6 Gene Expression in Human Monocytes by a Mechanism Independent of Protein Conformation

Peter Tabona, Krisanavane Reddi, Sahar Khan, Sean P. Nair, St. John V. Crean, Sajeda Meghji, Michael Wilson, Monika Preuss, Andrew D. Miller, Stephen Poole, Sandy Carne, and Brian Henderson
J Immunol 1998 161: 1414-1421. [Abstract] [Full Text] [PDF]  

Covalent Cross-Linking of Immune Complexes by Oxygen Radicals and Nitrite

Masaaki Uesugi, Takeshi Hayashi, and Hugo E. Jasin
J Immunol 1998 161: 1422-1427. [Abstract] [Full Text] [PDF]  

Host NK Cells Are Required for the Growth of the Human Filarial Parasite Brugia malayi in Mice

Subash Babu, Patricia Porte, Thomas R. Klei, Leonard D. Shultz, and T. V. Rajan
J Immunol 1998 161: 1428-1432. [Abstract] [Full Text] [PDF]  

Bcl-2-Mediated Inhibition of Apoptosis Prevents Immunogenicity and Restores Tumorigenicity of Spontaneously Regressive Tumors

Bernard Bonnotte, Nathalie Favre, Monique Moutet, Annie Fromentin, Eric Solary, Monique Martin, and François Martin
J Immunol 1998 161: 1433-1438. [Abstract] [Full Text] [PDF]  

Gene Knockout B Cell-Deficient Mice Demonstrate That B Cells Play an Important Role in the Initiation of T Cell Responses to Chlamydia trachomatis (Mouse Pneumonitis) Lung Infection

Xi Yang and Robert C. Brunham
J Immunol 1998 161: 1439-1446. [Abstract] [Full Text] [PDF]  

Control of IL-12 and IFN- Production in Response to Live or Dead Bacteria by TNF and Other Factors

Yifan Zhan and Christina Cheers
J Immunol 1998 161: 1447-1453. [Abstract] [Full Text] [PDF]  

In Vivo Retargeting of T Cell Effector Function by Recombinant Bispecific Single Chain Fv (Anti-CD3 x Anti-Idiotype) Induces Long-Term Survival in the Murine BCL1 Lymphoma Model

Jan De Jonge, Carlo Heirman, Marijke de Veerman, Sonja Van Meirvenne, Muriel Moser, Oberdan Leo, and Kris Thielemans
J Immunol 1998 161: 1454-1461. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Fibrinogen Activates NF-B Transcription Factors in Mononuclear Phagocytes

Robert G. Sitrin, Pauline M. Pan, Sujata Srikanth, and Robert F. Todd, III
J Immunol 1998 161: 1462-1470. [Abstract] [Full Text] [PDF]  

IL-10 Regulates Thrombus-Induced Vein Wall Inflammation and Thrombosis

L. Joseph Downing, Robert M. Strieter, Amy M. Kadell, Carol A. Wilke, John C. Austin, Bradley D. Hare, Marie D. Burdick, Lazar J. Greenfield, and Thomas W. Wakefield
J Immunol 1998 161: 1471-1476. [Abstract] [Full Text] [PDF]  

Absence of T Lymphocyte-Derived Cytokines Fails to Diminish Macrophage 12/15-Lipoxygenase Expression In Vivo

Sandra M. Sendobry, Joseph A. Cornicelli, Kathryn Welch, Michael J. Grusby, and Alan Daugherty
J Immunol 1998 161: 1477-1482. [Abstract] [Full Text] [PDF]  

LPS-Stimulated SJL Macrophages Produce IL-12 and IL-18 That Inhibit IgE Production In Vitro by Induction of IFN- Production from CD3^intIL-2Rß⁺ T Cells

Tomohiro Yoshimoto, Nobuhiko Nagai, Kazunobu Ohkusu, Haruyasu Ueda, Haruki Okamura, and Kenji Nakanishi
J Immunol 1998 161: 1483-1492. [Abstract] [Full Text] [PDF]  

Platelet-Activating Factor Synthesized by IL-12-Stimulated Polymorphonuclear Neutrophils and NK Cells Mediates Chemotaxis

Benedetta Bussolati, Filippo Mariano, Alessandro Cignetti, Anna Guarini, Vincenzo Cambi, Robert Foà, Giuseppe Piccoli, and Giovanni Camussi
J Immunol 1998 161: 1493-1500. [Abstract] [Full Text] [PDF]  

A Novel T Cell-Regulated Mechanism Modulating Allergen-Induced Airways Hyperreactivity in BALB/c Mice Independently of IL-4 and IL-5

Simon P. Hogan, Klaus I. Matthaei, Janine M. Young, Aulikki Koskinen, Ian G. Young, and Paul S. Foster
J Immunol 1998 161: 1501-1509. [Abstract] [Full Text] [PDF]  

Secretory IgA Induces Degranulation of IL-3-Primed Basophils

Motoyasu Iikura, Masao Yamaguchi, Takao Fujisawa, Misato Miyamasu, Toshiaki Takaishi, Yutaka Morita, Takashi Iwase, Itaru Moro, Kazuhiko Yamamoto, and Koichi Hirai
J Immunol 1998 161: 1510-1515. [Abstract] [Full Text] [PDF]  

Inhibition of Collagen-Induced Arthritis in Mice by Viral IL-10 Gene Transfer

Yuhe Ma, Sherry Thornton, Laura E. Duwel, Gregory P. Boivin, Edward H. Giannini, Jeffrey M. Leiden, Jeffrey A. Bluestone, and Raphael Hirsch
J Immunol 1998 161: 1516-1524. [Abstract] [Full Text] [PDF]  

Sustained Phosphorylation of Cytosolic Phospholipase A₂ Accompanies Cycloheximide- and Adenovirus-Induced Susceptibility to TNF

Jennifer B. O’Brien, Debra L. Piddington, Christina Voelkel-Johnson, Debra J. Richards, Leslie A. Hadley, and Scott M. Laster
J Immunol 1998 161: 1525-1532. [Abstract] [Full Text] [PDF]  

Endothelial Myosin Light Chain Kinase Regulates Neutrophil Migration Across Human Umbilical Vein Endothelial Cell Monolayer

Hajime Saito, Yoshihiro Minamiya, Michihiko Kitamura, Satoshi Saito, Katsuhiko Enomoto, Kunihiko Terada, and Jun-ichi Ogawa
J Immunol 1998 161: 1533-1540. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Reduced Susceptibility to Collagen-Induced Arthritis in Mice Deficient in IFN- Receptor

Yasunori Kageyama, Yukio Koide1, Atsushi Yoshida, Masato Uchijima, Tomio Arai, Shigehito Miyamoto, Takao Ozeki, Mitsuru Hiyoshi, Kazuhiro Kushida, and Tetsuo Inoue
J Immunol 1998 161: 1542-1548. [Abstract] [Full Text] [PDF]  

Circulating Form of Human Vascular Adhesion Protein-1 (VAP-1): Increased Serum Levels in Inflammatory Liver Diseases

Riikka Kurkijärvi, David H. Adams, Rauli Leino, Timo Möttönen, Sirpa Jalkanen, and Marko Salmi
J Immunol 1998 161: 1549-1557. [Abstract] [Full Text] [PDF]  

Involvement of the Fas/Fas Ligand Pathway in Activation-Induced Cell Death of Mycobacteria-Reactive Human T Cells: A Mechanism for the Loss of T Cells in Patients with Pulmonary Tuberculosis

Baiqing Li, Hamid Bassiri, Milton D. Rossman, Peter Kramer, A. Fusun-Oner Eyuboglu, Martha Torres, Eduardo Sada, Turgut Imir, and Simon R. Carding
J Immunol 1998 161: 1558-1567. [Abstract] [Full Text] [PDF]  

Antagonistic Action of IFN-ß and IFN- on High Affinity Fc Receptor Expression in Healthy Controls and Multiple Sclerosis Patients

Johan Van Weyenbergh, Pawel Lipinski, Annie Abadie, Dorothée Chabas, Ulrich Blank, Roland Liblau, and Juana Wietzerbin
J Immunol 1998 161: 1568-1574. [Abstract] [Full Text] [PDF]  

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