CUTTING EDGE:

Cutting Edge: CD40 Ligand Is Not Essential for the Development of Cell-Mediated Immunity and Resistance to Mycobacterium tuberculosis

Antonio Campos-Neto, Pamela Ovendale, Teresa Bement, Thelma A. Koppi, William C. Fanslow, Marcos A. Rossi, and Mark R. Alderson
J Immunol 1998 160: 2037-2041. [Abstract] [Full Text] [PDF]  

Cutting Edge: Constitutive Activation of TCR Signaling Molecules in IL-2-Independent Herpesvirus saimiri-Transformed T Cells

Nelly Noraz, Kunal Saha, Florence Ottones, Susan Smith, and Naomi Taylor
J Immunol 1998 160: 2042-2045. [Abstract] [Full Text] [PDF]  

Cutting Edge: Apoptosis Induced by a Chimeric Fas/FLICE Receptor: Lack of Requirement for Fas- or FADD-Binding Proteins

Sarfraz A. Memon, Jing-zhou Hou, M. Belen Moreno, and Charles M. Zacharchuk
J Immunol 1998 160: 2046-2049. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Antigen-Specific IgG Responses from Naive Human Splenocytes: In Vitro Priming Followed by Antigen Boost in the SCID Mouse

Peter Brams, Mai-Lan Nguyen, Soulaima Chamat, Ivor Royston, and Phillip R. Morrow
J Immunol 1998 160: 2051-2058. [Abstract] [Full Text] [PDF]  

IFN- Is Critical for Long-Term Allograft Survival Induced by Blocking the CD28 and CD40 Ligand T Cell Costimulation Pathways

Bogumila T. Konieczny, Zhenhua Dai, Eric T. Elwood, Sohail Saleem, Peter S. Linsley, Fady K. Baddoura, Christian P. Larsen, Thomas C. Pearson, and Fadi G. Lakkis
J Immunol 1998 160: 2059-2064. [Abstract] [Full Text] [PDF]  

Functional Roles of Fas and Bcl-2-Regulated Apoptosis of T Lymphocytes

Luk Van Parijs, Andre Biuckians, and Abul K. Abbas
J Immunol 1998 160: 2065-2071. [Abstract] [Full Text] [PDF]  

Activation of Human T Cells with Superantigen (Staphylococcal Enterotoxin B) and CD28 Confers Resistance to Apoptosis via CD95

Julie D. McLeod, Lucy S. K. Walker, Yusuf I. Patel, George Boulougouris, and David M. Sansom
J Immunol 1998 160: 2072-2079. [Abstract] [Full Text] [PDF]  

IL-12 Reverses Established Antigen-Specific Tolerance of Contact Sensitivity by Affecting Costimulatory Molecules B7-1 (CD80) and B7-2 (CD86)

Hiroko Ushio, Ryohei F. Tsuji, Marian Szczepanik, Keiko Kawamoto, Hiroshi Matsuda, and Philip W. Askenase
J Immunol 1998 160: 2080-2088. [Abstract] [Full Text] [PDF]  

A Novel Role for TGF-ß and IL-10 in the Induction of Immune Privilege

Thomas J. D’Orazio and Jerry Y. Niederkorn
J Immunol 1998 160: 2089-2098. [Abstract] [Full Text] [PDF]  

Human Melanoma Patients Recognize an HLA-A1-Restricted CTL Epitope from Tyrosinase Containing Two Cysteine Residues: Implications for Tumor Vaccine Development

David J. Kittlesen, Lee W. Thompson, Pamela H. Gulden, Jonathan C. A. Skipper, Teresa A. Colella, Jeffrey A. Shabanowitz, Donald F. Hunt, Victor H. Engelhard, and Craig L. Slingluff, Jr.
J Immunol 1998 160: 2099-2106. [Abstract] [Full Text] [PDF]  

Structural Dichotomy of Staphylococcal Enterotoxin C Superantigens Leading to MHC Class II-Independent Activation of T Lymphocytes

James G. Lamphear, Gregory A. Bohach, and Robert R. Rich
J Immunol 1998 160: 2107-2114. [Abstract] [Full Text] [PDF]  

Synergistic Activation of CD4⁺ T Cells by IL-16 and IL-2

Nereida A. Parada, David M. Center, Hardy Kornfeld, Wilma L. Rodriguez, Jennifer Cook, Margaret Vallen, and William W. Cruikshank
J Immunol 1998 160: 2115-2120. [Abstract] [Full Text] [PDF]  

Differential Coupling of Membrane Ig and CD40 to the Extracellularly Regulated Kinase Signaling Pathway

Jeffrey M. Purkerson and David C. Parker
J Immunol 1998 160: 2121-2129. [Abstract] [Full Text] [PDF]  

Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis

Sue J. Sohn, Katherine A. Forbush, Nhan Nguyen, Bruce Witthuhn, Tetsuya Nosaka, James N. Ihle, and Roger M. Perlmutter
J Immunol 1998 160: 2130-2138. [Abstract] [Full Text] [PDF]  

Differential Presentation of the Same MHC Class I Epitopes by Fibroblasts and Dendritic Cells

Eric A. Butz and Michael J. Bevan
J Immunol 1998 160: 2139-2144. [Abstract] [Full Text] [PDF]  

CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM⁺IgD⁺ B Cell Line

Andrea Cerutti, Hong Zan, Andras Schaffer, Leif Bergsagel, Nagaradona Harindranath, Edward E. Max, and Paolo Casali
J Immunol 1998 160: 2145-2157. [Abstract] [Full Text] [PDF]  

Anti-CD40 Ligand Antibody Treatment of SNF₁ Mice with Established Nephritis: Preservation of Kidney Function

Susan L. Kalled, Anne H. Cutler, Syamal K. Datta, and David W. Thomas
J Immunol 1998 160: 2158-2165. [Abstract] [Full Text] [PDF]  

Heterogeneity of Mouse Spleen Dendritic Cells: In Vivo Phagocytic Activity, Expression of Macrophage Markers, and Subpopulation Turnover

Pieter J. M. Leenen, Katarina Radosevic, Jane S. A. Voerman, Benoît Salomon, Nico van Rooijen, David Klatzmann, and Willem van Ewijk
J Immunol 1998 160: 2166-2173. [Abstract] [Full Text] [PDF]  

Analysis of the Multiple Interactions Between IL-12 and the High Affinity IL-12 Receptor Complex

David H. Presky, Lisa J. Minetti, Silke Gillessen, Victoria L. Wilkinson, Chang-You Wu, Ueli Gubler, Richard Chizzonite, and Maurice K. Gately
J Immunol 1998 160: 2174-2179. [Abstract] [Full Text] [PDF]  

Expression of the Costimulatory Receptor CD30 Is Regulated by Both CD28 and Cytokines

Molly C. Gilfillan, Patricia J. Noel, Eckhard R. Podack, Steven L. Reiner, and Craig B. Thompson
J Immunol 1998 160: 2180-2187. [Abstract] [Full Text] [PDF]  

A Mucosal Intranet: Intestinal Epithelial Cells Down-Regulate Intraepithelial, But Not Peripheral, T Lymphocytes

Masafumi Yamamoto, Kohtaro Fujihashi, Keiko Kawabata, Jerry R. McGhee, and Hiroshi Kiyono
J Immunol 1998 160: 2188-2196. [Abstract] [Full Text] [PDF]  

Fetal Mouse NK Cell Clones Are Deficient in Ly49 Expression, Share a Common Broad Lytic Specificity, and Undergo Continuous and Extensive Diversification In Vitro

Maria S. Manoussaka, Rachel J. Smith, Victoria Conlin, Jennifer A. Toomey, and Colin G. Brooks
J Immunol 1998 160: 2197-2206. [Abstract] [Full Text] [PDF]  

Different Protein Kinase C Isoenzymes Regulate IL-2 Receptor Expression or IL-2 Synthesis in Human Lymphocytes Stimulated via the TCR

Marta Szamel, Annette Appel, Reinhard Schwinzer, and Klaus Resch
J Immunol 1998 160: 2207-2214. [Abstract] [Full Text] [PDF]  

Inhibition of Cell Cycle Progression by a Synthetic Peptide Corresponding to Residues 65–79 of an HLA Class II Sequence: Functional Similarities but Mechanistic Differences with the Immunosuppressive Drug Rapamycin

Michelle L. Boytim, Shu-Chen Lyu, Ron Jung, Alan M. Krensky, and Carol Clayberger
J Immunol 1998 160: 2215-2222. [Abstract] [Full Text] [PDF]  

CD28 Receptor Endocytosis Is Targeted by Mutations That Disrupt Phosphatidylinositol 3-Kinase Binding and Costimulation

Daniel Céfaï, Helga Schneider, Oranart Matangkasombut, Hyun Kang, Joshua Brody, and Christopher E. Rudd
J Immunol 1998 160: 2223-2230. [Abstract] [Full Text] [PDF]  

Corticosteroids Enhance the Capacity of Macrophages to Induce Th2 Cytokine Synthesis in CD4⁺ Lymphocytes by Inhibiting IL-12 Production

Rosemarie H. DeKruyff, Yu Fang, and Dale T. Umetsu
J Immunol 1998 160: 2231-2237. [Abstract] [Full Text] [PDF]  

CD38 Functions Are Regulated Through an Internalization Step

Ada Funaro, Milan Reinis, Oriana Trubiani, Spartaco Santi, Roberto Di Primio, and Fabio Malavasi
J Immunol 1998 160: 2238-2247. [Abstract] [Full Text] [PDF]  

Generation of an Inhibitory Circuit Involving CD8⁺ T Cells, IL-2, and NK Cell-Derived TGF-ß: Contrasting Effects of Anti-CD2 and Anti-CD3

J. Dixon Gray, Makoto Hirokawa, Kazuo Ohtsuka, and David A. Horwitz
J Immunol 1998 160: 2248-2254. [Abstract] [Full Text] [PDF]  

IL-4 Enhances Long-Term Survival of CD28-Deficient T Cells

Risa M. Stack, Craig B. Thompson, and Frank W. Fitch
J Immunol 1998 160: 2255-2262. [Abstract] [Full Text] [PDF]  

Maternal Ig Mediates Neonatal Tolerance in Rheumatoid Factor Transgenic Mice but Tolerance Breaks Down in Adult Mice

Haowei Wang and Mark J. Shlomchik
J Immunol 1998 160: 2263-2271. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). I. Production of the Non-IL-7 Component by Bone Marrow Stromal Cells from IL-7 Gene-Deleted Mice

Sean D. McKenna, Fangqi Chen, Laijun Lai, and Irving Goldschneider
J Immunol 1998 160: 2272-2279. [Abstract] [Full Text] [PDF]  

Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). II. PPBSF Is a Covalently Linked Heterodimer of IL-7 and a M_r 30,000 Cofactor

Laijun Lai, Fangqi Chen, Sean McKenna, and Irving Goldschneider
J Immunol 1998 160: 2280-2286. [Abstract] [Full Text] [PDF]  

PU.1/Spi-1 Is Essential for the B Cell-Specific Activity of the Mouse CD72 Promoter

Han Ying, Ju-Fay Chang, and Jane R. Parnes
J Immunol 1998 160: 2287-2296. [Abstract] [Full Text] [PDF]  

Characterization of the Interactions Between MHC Class I Subunits: A Systematic Approach for the Engineering of Higher Affinity Variants of ß₂-Microglobulin

Michael J. Shields, Nassim Assefi, Wesley Hodgson, Ellen J. Kim, and Randall K. Ribaudo
J Immunol 1998 160: 2297-2307. [Abstract] [Full Text] [PDF]  

Induction of Nuclear Factor-B During Primary B Cell Differentiation

Barbara Kistler, Antonius Rolink, Ralf Marienfeld, Manfred Neumann, and Thomas Wirth
J Immunol 1998 160: 2308-2317. [Abstract] [Full Text] [PDF]  

Antibody Binding to Individual Short Consensus Repeats of Decay-Accelerating Factor Enhances Enterovirus Cell Attachment and Infectivity

Darren R. Shafren, Douglas J. Dorahy, Rick F. Thorne, Taroh Kinoshita, Richard D. Barry, and Gordon F. Burns
J Immunol 1998 160: 2318-2323. [Abstract] [Full Text] [PDF]  

Distinct NFAT Family Proteins Are Involved in the Nuclear NFAT-DNA Binding Complexes from Human Thymocyte Subsets

Yoshiharu Amasaki, Esteban S. Masuda, Ryu Imamura, Ken-ichi Arai, and Naoko Arai
J Immunol 1998 160: 2324-2333. [Abstract] [Full Text] [PDF]  

Redundancy of C/EBP, -ß, and - in Supporting the Lipopolysaccharide-Induced Transcription of IL-6 and Monocyte Chemoattractant Protein-1

Hsien-Ming Hu, Mark Baer, Simon C. Williams, Peter F. Johnson, and Richard C. Schwartz
J Immunol 1998 160: 2334-2342. [Abstract] [Full Text] [PDF]  

Characterization of cis-Regulatory Elements and Nuclear Factors Conferring Th2-Specific Expression of the IL-5 Gene: A Role for a GATA-Binding Protein

Hyun Jun Lee, Anne O’Garra, Ken-ichi Arai, and Naoko Arai
J Immunol 1998 160: 2343-2352. [Abstract] [Full Text] [PDF]  

Analysis of BR96 Binding Sites for Antigen and Anti-Idiotype by Codon-Based Scanning Mutagenesis

Mae Joanne Rosok, Mohammad Eghtedarzadeh-Kondri, Kelly Young, Jürgen Bajorath, Scott Glaser, and Dale Yelton
J Immunol 1998 160: 2353-2359. [Abstract] [Full Text] [PDF]  

Base-Specific Sequences That Bias Somatic Hypermutation Deduced by Analysis of Out-of-Frame Human IgV_H Genes

Deborah K. Dunn-Walters, Ahmet Dogan, Laurent Boursier, Connie M. MacDonald, and Jo Spencer
J Immunol 1998 160: 2360-2364. [Abstract] [Full Text] [PDF]  

A Peptide Binding Motif for HLA-DQA1*0102/DQB1*0602, the Class II MHC Molecule Associated with Dominant Protection in Insulin-Dependent Diabetes Mellitus

Ruth A. Ettinger and William W. Kwok
J Immunol 1998 160: 2365-2373. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Human Purified Protein Derivative-Specific CD4⁺ T Cells Use Both CD95-Dependent and CD95-Independent Cytolytic Mechanisms

David M. Lewinsohn, Teresa T. Bement, Jiangchun Xu, David H. Lynch, Kenneth H. Grabstein, Steven G. Reed, and Mark R. Alderson
J Immunol 1998 160: 2374-2379. [Abstract] [Full Text] [PDF]  

Type 1- and Type 2-Like Lesional Skin-Derived Mycobacterium leprae-Responsive T Cell Clones Are Characterized by Coexpression of IFN-/TNF- and IL-4/IL-5/IL-13, Respectively

Claudia E. Verhagen, Tineke C. T. M. van der Pouw Kraan, Anita A. M. Buffing, Mohamed A. Chand, William R. Faber, Lucien A. Aarden, and Pranab K. Das
J Immunol 1998 160: 2380-2387. [Abstract] [Full Text] [PDF]  

Contribution of Cells at the Site of DNA Vaccination to the Generation of Antigen-Specific Immunity and Memory

Dennis M. Klinman, Joan M. G. Sechler, Jacqueline Conover, Mili Gu, and Amy S. Rosenberg
J Immunol 1998 160: 2388-2392. [Abstract] [Full Text] [PDF]  

IL-5 Is Required for Eosinophil Recruitment, Crystal Deposition, and Mononuclear Cell Recruitment During a Pulmonary Cryptococcus neoformans Infection in Genetically Susceptible Mice (C57BL/6)

Gary B. Huffnagle, Michael B. Boyd, Nancy E. Street, and Mary F. Lipscomb
J Immunol 1998 160: 2393-2400. [Abstract] [Full Text] [PDF]  

Activation of IL-8 Gene Expression by Helicobacter pylori Is Regulated by Transcription Factor Nuclear Factor-B in Gastric Epithelial Cells

Smita A. Sharma, Murali K. R. Tummuru, Martin J. Blaser, and Lawrence D. Kerr
J Immunol 1998 160: 2401-2407. [Abstract] [Full Text] [PDF]  

Lymphocyte-Dependent Inhibition of Growth of Virulent Mycobacterium tuberculosis H37Rv Within Human Monocytes: Requirement for CD4⁺ T Cells in Purified Protein Derivative-Positive, But Not in Purified Protein Derivative-Negative Subjects

Richard F. Silver, Qing Li, W. Henry Boom, and Jerrold J. Ellner
J Immunol 1998 160: 2408-2417. [Abstract] [Full Text] [PDF]  

CKß-11/Macrophage Inflammatory Protein-3ß/EBI1-Ligand Chemokine Is an Efficacious Chemoattractant for T and B Cells

Chang H. Kim, Louis M. Pelus, John R. White, Edward Applebaum, Kyung Johanson, and Hal E. Broxmeyer
J Immunol 1998 160: 2418-2424. [Abstract] [Full Text] [PDF]  

Induction of CD8⁺ T Cell Responses to Dominant and Subdominant Epitopes and Protective Immunity to Sendai Virus Infection by DNA Vaccination

Yongjin Chen, Robert G. Webster, and David L. Woodland
J Immunol 1998 160: 2425-2432. [Abstract] [Full Text] [PDF]  

Development of a Murine Mutant Ras CD8⁺ CTL Peptide Epitope Variant That Possesses Enhanced MHC Class I Binding and Immunogenic Properties

J. Andrew Bristol, Jeffrey Schlom, and Scott I. Abrams
J Immunol 1998 160: 2433-2441. [Abstract] [Full Text] [PDF]  

Granulocyte-Macrophage Colony-Stimulating Factor Enhances EBV-Induced Synthesis of Chemotactic Factors in Human Neutrophils

Charles J. Roberge, Shaun R. McColl, Bernard Larochelle, and Jean Gosselin
J Immunol 1998 160: 2442-2448. [Abstract] [Full Text] [PDF]  

A Helminth-Induced Mucosal Th2 Response Alters Nonresponsiveness to Oral Administration of a Soluble Antigen

Hai Ning Shi, Christian J. Ingui, Ingrid Dodge, and Cathryn Nagler-Anderson
J Immunol 1998 160: 2449-2455. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

The House Dust Mite Allergen, Dermatophagoides pteronyssinus, Promotes Type 2 Responses by Modulating the Balance Between IL-4 and IFN-

Emmanuel E. Comoy, Joel Pestel, Catherine Duez, Geoffrey A. Stewart, Catherine Vendeville, Charles Fournier, Fred Finkelman, André Capron, and Georges Thyphronitis
J Immunol 1998 160: 2456-2462. [Abstract] [Full Text] [PDF]  

Desensitization of Formyl Peptide Receptors Is Abolished in Calcium Ionophore-Primed Neutrophils: An Association of the Ligand-Receptor Complex to the Cytoskeleton Is Not Required for a Rapid Termination of the NADPH-Oxidase Response

Li Liu, Olle Harbecke, Hans Elwing, Per Follin, Anna Karlsson, and Claes Dahlgren
J Immunol 1998 160: 2463-2468. [Abstract] [Full Text] [PDF]  

Post-Translational Processing of Murine IL-1: Evidence that ATP-Induced Release of IL-1 and IL-1ß Occurs via a Similar Mechanism

David G. Perregaux and Christopher A. Gabel
J Immunol 1998 160: 2469-2477. [Abstract] [Full Text] [PDF]  

Mutation of Proline 211 Reduces Shedding of the Human p75 TNF Receptor

Charlotte Herman and Yuti Chernajovsky
J Immunol 1998 160: 2478-2487. [Abstract] [Full Text] [PDF]  

CD137 (ILA/4-1BB), a Member of the TNF Receptor Family, Induces Monocyte Activation via Bidirectional Signaling

Joachim Langstein, Jan Michel, Jana Fritsche, Marina Kreutz, Reinhard Andreesen, and Herbert Schwarz
J Immunol 1998 160: 2488-2494. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Mapping IgG Epitopes Bound by Rheumatoid Factors from Immunized Controls Identifies Disease-Specific Rheumatoid Factors Produced by Patients with Rheumatoid Arthritis

Vincent R. Bonagura, Nick Agostino, Marie Børretzen, Keith M. Thompson, Jacob B. Natvig, and Sherie L. Morrison
J Immunol 1998 160: 2496-2505. [Abstract] [Full Text] [PDF]  

HIV-1/Simian Immunodeficiency Virus Infection of Human and Nonhuman Primate Lymphocytes Results in the Migration of CD2⁺ T Cells into the Intestine of Engrafted SCID Mice

Hollie Hale Donze, James E. Cummins, Jr., Rebecca S. Schwiebert, Anu Kantele, Yuncheng Han, Patricia N. Fultz, Susan Jackson, and Jiri Mestecky
J Immunol 1998 160: 2506-2513. [Abstract] [Full Text] [PDF]  

Lymphoproliferative Disease in Human Peripheral Blood Mononuclear Cell-Injected SCID Mice. IV. Differential Activation of Human Th1 and Th2 Lymphocytes and Influence of the Atopic Status on Lymphoma Development

Vincenzo Coppola, Arianna Veronesi, Stefano Indraccolo, Francesca Calderazzo, Marta Mion, Sonia Minuzzo, Giovanni Esposito, Daniele Mauro, Barbara Silvestri, Paolo Gallo, Paolo Falagiani, Alberto Amadori, and Luigi Chieco-Bianchi
J Immunol 1998 160: 2514-2522. [Abstract] [Full Text] [PDF]  

Malaria Elicits Type 1 Cytokines in the Human Placenta: IFN- and TNF- Associated with Pregnancy Outcomes

Michal Fried, Richard O. Muga, Ambrose O. Misore, and Patrick E. Duffy
J Immunol 1998 160: 2523-2530. [Abstract] [Full Text] [PDF]  

A Double Recombinant Adenovirus Expressing the Costimulatory Molecule B7-1 (Murine) and Human IL-2 Induces Complete Tumor Regression in a Murine Breast Adenocarcinoma Model

Peter C. R. Emtage, Yonghong Wan, Jonathan L. Bramson, Frank L. Graham, and Jack Gauldie
J Immunol 1998 160: 2531-2538. [Abstract] [Full Text] [PDF]  

Decreased Production of TGF-ß by Lymphocytes from Patients with Systemic Lupus Erythematosus

Kazuo Ohtsuka, J. Dixon Gray, Mary M. Stimmler, Bricia Toro, and David A. Horwitz
J Immunol 1998 160: 2539-2545. [Abstract] [Full Text] [PDF]  

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