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*
Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Canada;
Department of Immunology, University of Alberta, Edmonton, Alberta, Canada; and
Human Health Research Center, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada
NK-mediated cytotoxicity involves two families of receptors: activating receptors that trigger lysis of the target cells being recognized and inhibitory receptors specific primarily for MHC I on the target cell surface that can override the activating signal. MHC I molecules on the cell surface can be classified into molecules made stable by the binding of peptide with high affinity or unstable molecules potentially capable of binding high affinity peptide (hence, peptide receptive) and being converted into stable molecules. It has been previously shown that the Ly-49A inhibitory receptor recognizes stable Dd molecules. We show in this study that the inhibitory receptor Ly-49CB6 recognizes peptide-receptive Kb molecules, but does not recognize Kb molecules once they have bound high affinity peptide.
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