The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Daly, T. M.
Right arrow Articles by Long, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Daly, T. M.
Right arrow Articles by Long, C. A.

The Journal of Immunology, Vol 155, Issue 1 236-243, Copyright © 1995 by American Association of Immunologists

ARTICLES

Humoral response to a carboxyl-terminal region of the merozoite surface protein-1 plays a predominant role in controlling blood-stage infection in rodent malaria

TM Daly and CA Long
Department of Microbiology and Immunology, Medical College of Pennsylvania, Philadelphia 19102, USA.

The developmental stages of malaria parasites that infect E are responsible for the morbidity and mortality associated with this disease. One of the leading candidates for a blood-stage vaccine against malaria is a surface protein of merozoites, the infectious stages for E, designated merozoite surface protein-1 (MSP-1). The rodent malarial parasite Plasmodium yoelii yoelii (Py) has provided a model system for the study of this Ag, and previous studies from our laboratory had demonstrated that the carboxyl-terminal, cysteine-rich region of MSP-1, when expressed in a native configuration, could immunize mice against a normally lethal challenge infection with Py. We have now prepared a new fusion construct with the glutathione-S- transferase gene of Schistosoma japonicum joined to the carboxyl- terminal 11 kDa of Py MSP-1. This includes only the two epidermal growth factor-like domains of the MSP-1 protein. When expressed in recombinant Escherichia coli, the fusion protein induces a strong protective response in BALB/c mice as judged by the resistance of immunized animals to a virulent challenge infection. Moreover, we demonstrate that this resistance can be transferred passively by immune serum or by purified Ig, establishing a significant role for humoral immunity in protection. No role for CD4+ or CD8+ T cells could be identified in the first 12 days after challenge infection in immune mice selectively depleted of these cells; however, after this time, parasitemias gradually increased in mice depleted of CD4+ T cells, suggesting an active host response is necessary to completely eliminate the infection.


This article has been cited by other articles:


Home page
 CVIHome page
M. M. Lynch, A. Cernetich-Ott, W. P. Weidanz, and J. M. Burns Jr.
Prediction of Merozoite Surface Protein 1 and Apical Membrane Antigen 1 Vaccine Efficacies against Plasmodium chabaudi Malaria Based on Prechallenge Antibody Responses
Clin. Vaccine Immunol., March 1, 2009; 16(3): 293 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Wipasa, H. Xu, X. Liu, C. Hirunpetcharat, A. Stowers, and M. F. Good
Effect of Plasmodium yoelii Exposure on Vaccination with the 19-Kilodalton Carboxyl Terminus of Merozoite Surface Protein 1 and Vice Versa and Implications for the Application of a Human Malaria Vaccine
Infect. Immun., February 1, 2009; 77(2): 817 - 824.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. M. Petritus and J. M. Burns Jr.
Suppression of Lethal Plasmodium yoelii Malaria following Protective Immunization Requires Antibody-, IL-4-, and IFN-{gamma}-Dependent Responses Induced by Vaccination and/or Challenge Infection
J. Immunol., January 1, 2008; 180(1): 444 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
X.-J. Cheng, H. Hayasaka, K. Watanabe, Y.-L. Tao, J.-Y. Liu, H. Tsukamoto, T. Horii, K. Tanabe, and H. Tachibana
Production of High-Affinity Human Monoclonal Antibody Fab Fragments to the 19-Kilodalton C-Terminal Merozoite Surface Protein 1 of Plasmodium falciparum
Infect. Immun., July 1, 2007; 75(7): 3614 - 3620.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Q. Shi, M. M. Lynch, M. Romero, and J. M. Burns Jr.
Enhanced Protection against Malaria by a Chimeric Merozoite Surface Protein Vaccine
Infect. Immun., March 1, 2007; 75(3): 1349 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Singh, K. Miura, H. Zhou, O. Muratova, B. Keegan, A. Miles, L. B. Martin, A. J. Saul, L. H. Miller, and C. A. Long
Immunity to Recombinant Plasmodium falciparum Merozoite Surface Protein 1 (MSP1): Protection in Aotus nancymai Monkeys Strongly Correlates with Anti-MSP1 Antibody Titer and In Vitro Parasite-Inhibitory Activity.
Infect. Immun., August 1, 2006; 74(8): 4573 - 4580.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Q. Shi, A. Cernetich, T. M. Daly, G. Galvan, A. B. Vaidya, L. W. Bergman, and J. M. Burns Jr
Alteration in Host Cell Tropism Limits the Efficacy of Immunization with a Surface Protein of Malaria Merozoites
Infect. Immun., October 1, 2005; 73(10): 6363 - 6371.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. N. Wykes, Y.-H. Zhou, X. Q. Liu, and M. F. Good
Plasmodium yoelii Can Ablate Vaccine-Induced Long-Term Protection in Mice
J. Immunol., August 15, 2005; 175(4): 2510 - 2516.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
I.-K. YOON, E. ANGOV, D. LARSON, D. G. HEPPNER, J. F. CUMMINGS, and V. A. STEWART
CHARACTERIZATION OF A HUMAN REFERENCE STANDARD FOR ANTIBODY TO PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 142
Am J Trop Med Hyg, June 1, 2005; 72(6): 714 - 718.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. M. Burns Jr., P. R. Flaherty, P. Nanavati, and W. P. Weidanz
Protection against Plasmodium chabaudi Malaria Induced by Immunization with Apical Membrane Antigen 1 and Merozoite Surface Protein 1 in the Absence of Gamma Interferon or Interleukin-4
Infect. Immun., October 1, 2004; 72(10): 5605 - 5612.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Sachdeva, G. Ahmad, P. Malhotra, P. Mukherjee, and V. S. Chauhan
Comparison of Immunogenicities of Recombinant Plasmodium vivax Merozoite Surface Protein 1 19- and 42-Kilodalton Fragments Expressed in Escherichia coli
Infect. Immun., October 1, 2004; 72(10): 5775 - 5782.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. C. John, R. A. O'Donnell, P. O. Sumba, A. M. Moormann, T. F. de Koning-Ward, C. L. King, J. W. Kazura, and B. S. Crabb
Evidence That Invasion-Inhibitory Antibodies Specific for the 19-kDa Fragment of Merozoite Surface Protein-1 (MSP-119) Can Play a Protective Role against Blood-Stage Plasmodium falciparum Infection in Individuals in a Malaria Endemic Area of Africa
J. Immunol., July 1, 2004; 173(1): 666 - 672.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. R. Drew, R. A. O'Donnell, B. J. Smith, and B. S. Crabb
A Common Cross-species Function for the Double Epidermal Growth Factor-like Modules of the Highly Divergent Plasmodium Surface Proteins MSP-1 and MSP-8
J. Biol. Chem., May 7, 2004; 279(19): 20147 - 20153.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Kumar, T. R. Jones, M. S. Oakley, H. Zheng, S. P. Kuppusamy, A. Taye, A. M. Krieg, A. W. Stowers, D. C. Kaslow, and S. L. Hoffman
CpG Oligodeoxynucleotide and Montanide ISA 51 Adjuvant Combination Enhanced the Protective Efficacy of a Subunit Malaria Vaccine
Infect. Immun., February 1, 2004; 72(2): 949 - 957.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Mello, T. M. Daly, C. A. Long, J. M. Burns, and L. W. Bergman
Members of the Merozoite Surface Protein 7 Family with Similar Expression Patterns Differ in Ability To Protect against Plasmodium yoelii Malaria
Infect. Immun., February 1, 2004; 72(2): 1010 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Singh, M. C. Kennedy, C. A. Long, A. J. Saul, L. H. Miller, and A. W. Stowers
Biochemical and Immunological Characterization of Bacterially Expressed and Refolded Plasmodium falciparum 42-Kilodalton C-Terminal Merozoite Surface Protein 1
Infect. Immun., December 1, 2003; 71(12): 6766 - 6774.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Rainczuk, T. Scorza, P. M. Smooker, and T. W. Spithill
Induction of Specific T-Cell Responses, Opsonizing Antibodies, and Protection against Plasmodium chabaudi adami Infection in Mice Vaccinated with Genomic Expression Libraries Expressed in Targeted and Secretory DNA Vectors
Infect. Immun., August 1, 2003; 71(8): 4506 - 4515.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. Kedzierski, C. G. Black, M. W. Goschnick, A. W. Stowers, and R. L. Coppel
Immunization with a Combination of Merozoite Surface Proteins 4/5 and 1 Enhances Protection against Lethal Challenge with Plasmodium yoelii
Infect. Immun., December 1, 2002; 70(12): 6606 - 6613.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
K. Mello, T. M. Daly, J. Morrisey, A. B. Vaidya, C. A. Long, and L. W. Bergman
A Multigene Family That Interacts with the Amino Terminus of Plasmodium MSP-1 Identified Using the Yeast Two-Hybrid System
Eukaryot. Cell, December 1, 2002; 1(6): 915 - 925.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Wipasa, H. Xu, M. Makobongo, M. Gatton, A. Stowers, and M. F. Good
Nature and Specificity of the Required Protective Immune Response That Develops Postchallenge in Mice Vaccinated with the 19-Kilodalton Fragment of Plasmodium yoelii Merozoite Surface Protein 1
Infect. Immun., November 1, 2002; 70(11): 6013 - 6020.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. A. Near, A. W. Stowers, D. Jankovic, and D. C. Kaslow
Improved Immunogenicity and Efficacy of the Recombinant 19-Kilodalton Merozoite Surface Protein 1 by the Addition of Oligodeoxynucleotide and Aluminum Hydroxide Gel in a Murine Malaria Vaccine Model
Infect. Immun., February 1, 2002; 70(2): 692 - 701.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. Ahlborg, I. T. Ling, W. Howard, A. A. Holder, and E. M. Riley
Protective Immune Responses to the 42-Kilodalton (kDa) Region of Plasmodium yoelii Merozoite Surface Protein 1 Are Induced by the C-Terminal 19-kDa Region but Not by the Adjacent 33-kDa Region
Infect. Immun., February 1, 2002; 70(2): 820 - 825.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. L. King, I. Malhotra, A. Wamachi, J. Kioko, P. Mungai, S. A. Wahab, D. Koech, P. Zimmerman, J. Ouma, and J. W. Kazura
Acquired Immune Responses to Plasmodium falciparum Merozoite Surface Protein-1 in the Human Fetus
J. Immunol., January 1, 2002; 168(1): 356 - 364.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Wipasa, H. Xu, A. Stowers, and M. F. Good
Apoptotic Deletion of Th Cells Specific for the 19-kDa Carboxyl-Terminal Fragment of Merozoite Surface Protein 1 During Malaria Infection
J. Immunol., October 1, 2001; 167(7): 3903 - 3909.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
R. A. O'Donnell, T. F. de Koning-Ward, R. A. Burt, M. Bockarie, J. C. Reeder, A. F. Cowman, and B. S. Crabb
Antibodies against Merozoite Surface Protein (Msp)-119 Are a Major Component of the Invasion-Inhibitory Response in Individuals Immune to Malaria
J. Exp. Med., June 18, 2001; 193(12): 1403 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. W. Stowers, V. Cioce, R. L. Shimp, M. Lawson, G. Hui, O. Muratova, D. C. Kaslow, R. Robinson, C. A. Long, and L. H. Miller
Efficacy of Two Alternate Vaccines Based on Plasmodium falciparum Merozoite Surface Protein 1 in an Aotus Challenge Trial
Infect. Immun., March 1, 2001; 69(3): 1536 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. M. Burns Jr., C. C. Belk, and P. D. Dunn
A Protective Glycosylphosphatidylinositol-Anchored Membrane Protein of Plasmodium yoelii Trophozoites and Merozoites Contains Two Epidermal Growth Factor-Like Domains
Infect. Immun., November 1, 2000; 68(11): 6189 - 6195.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. Wunderlich, I. C. Moura, and H. A. del Portillo
Genetic Immunization of BALB/c mice with a Plasmid Bearing the Gene Coding for a Hybrid Merozoite Surface Protein 1-Hepatitis B Virus Surface Protein Fusion Protects Mice against Lethal Plasmodium chabaudi chabaudi PC1 Infection
Infect. Immun., October 1, 2000; 68(10): 5839 - 5845.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. Kedzierski, C. G. Black, and R. L. Coppel
Immunization with Recombinant Plasmodium yoelii Merozoite Surface Protein 4/5 Protects Mice against Lethal Challenge
Infect. Immun., October 1, 2000; 68(10): 6034 - 6037.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. Ahlborg, I. T. Ling, A. A. Holder, and E. M. Riley
Linkage of Exogenous T-cell Epitopes to the 19-Kilodalton Region of Plasmodium yoelii Merozoite Surface Protein 1 (MSP119) Can Enhance Protective Immunity against Malaria and Modulate the Immunoglobulin Subclass Response to MSP119
Infect. Immun., April 1, 2000; 68(4): 2102 - 2109.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Kumar, W. Collins, A. Egan, A. Yadava, O. Garraud, M. J. Blackman, J. A. G. Patino, C. Diggs, and D. C. Kaslow
Immunogenicity and Efficacy in Aotus Monkeys of Four Recombinant Plasmodium falciparum Vaccines in Multiple Adjuvant Formulations Based on the 19-Kilodalton C Terminus of Merozoite Surface Protein 1
Infect. Immun., April 1, 2000; 68(4): 2215 - 2223.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Hirunpetcharat, P. Vukovic, X. Q. Liu, D. C. Kaslow, L. H. Miller, and M. F. Good
Absolute Requirement for an Active Immune Response Involving B Cells and Th Cells in Immunity to Plasmodium yoelii Passively Acquired with Antibodies to the 19-kDa Carboxyl-Terminal Fragment of Merozoite Surface Protein-1
J. Immunol., June 15, 1999; 162(12): 7309 - 7314.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. G. Black, L. Wang, A. R. Hibbs, E. Werner, and R. L. Coppel
Identification of the Plasmodium chabaudi Homologue of Merozoite Surface Proteins 4 and 5 of Plasmodium falciparum
Infect. Immun., May 1, 1999; 67(5): 2075 - 2081.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. M. Burns Jr., E. K. Adeeku, and P. D. Dunn
Protective Immunization with a Novel Membrane Protein of Plasmodium yoelii-Infected Erythrocytes
Infect. Immun., February 1, 1999; 67(2): 675 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. S. N. Hui and C. N. Hashimoto
Pathways for Potentiation of Immunogenicity during Adjuvant-Assisted Immunizations with Plasmodium falciparum Major Merozoite Surface Protein 1
Infect. Immun., November 1, 1998; 66(11): 5329 - 5336.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Kang, P. A. Calvo, T. M. Daly, and C. A. Long
Comparison of Humoral Immune Responses Elicited by DNA and Protein Vaccines Based on Merozoite Surface Protein-1 from Plasmodium yoelii, a Rodent Malaria Parasite
J. Immunol., October 15, 1998; 161(8): 4211 - 4219.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Matsumoto, H. Yukitake, H. Kanbara, and T. Yamada
Recombinant Mycobacterium bovis Bacillus Calmette-Guerin Secreting Merozoite Surface Protein 1 (MSP1) Induces Protection against Rodent Malaria Parasite Infection Depending on MSP1-stimulated Interferon {gamma} and Parasite-specific Antibodies
J. Exp. Med., September 7, 1998; 188(5): 845 - 854.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. L. Rotman, T. M. Daly, R. Clynes, and C. A. Long
Fc Receptors Are Not Required for Antibody-Mediated Protection Against Lethal Malaria Challenge in a Mouse Model
J. Immunol., August 15, 1998; 161(4): 1908 - 1912.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. M. Spencer Valero, S. A. Ogun, S. L. Fleck, I. T. Ling, T. J. Scott-Finnigan, M. J. Blackman, and A. A. Holder
Passive Immunization with Antibodies against Three Distinct Epitopes on Plasmodium yoelii Merozoite Surface Protein 1 Suppresses Parasitemia
Infect. Immun., August 1, 1998; 66(8): 3925 - 3930.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. I. Becker, R. Wang, R. C. Hedstrom, J. C. Aguiar, T. R. Jones, S. L. Hoffman, and M. J. Gardner
Protection of Mice against Plasmodium yoelii Sporozoite Challenge with P. yoelii Merozoite Surface Protein 1 DNA Vaccines
Infect. Immun., July 1, 1998; 66(7): 3457 - 3461.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.