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The Journal of Immunology, Vol 155, Issue 1 203-209, Copyright © 1995 by American Association of Immunologists

ARTICLES

Molecular cloning and functional characterization of human lymphotactin

J Kennedy, GS Kelner, S Kleyensteuber, TJ Schall, MC Weiss, H Yssel, PV Schneider, BG Cocks, KB Bacon and A Zlotnik
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.

We describe the isolation of a cDNA that encodes human lymphotactin (Ltn), a new class of lymphocyte-specific chemokine. Human Ltn shows similarity to some members of the C-C chemokine family but has lost the first and third cysteine residues that are characteristic of the C-C and C-X-C chemokines. Ltn is chemotactic for lymphocytes but not for monocytes, a characteristic that makes it unique among chemokines. In addition, calcium flux desensitization studies indicate that Ltn uses a unique receptor. The human Ltn gene maps to a different chromosome than do the C-C and C-X-C chemokine families. Taken together, these characteristics indicate that Ltn is the first example of a new class of human chemokines with preferential effects on lymphocytes.


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